Trial reportTranslational psychiatry2025
Investigating the effects of brain stimulation on the neural substrates of inhibition in patients with OCD: A simultaneous tDCS - fMRI study.
Trial report in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Linking electric field directionality to treatment outcome in OCD: Insights from patient-specific tDCS modeling.Translational psychiatry · 2026Trial
- Sensorimotor circuit connectivity as a candidate biomarker for responsiveness to sertraline in obsessive-compulsive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Neurochemically informed network control theory reveals energetic dysregulation of altered brain state dynamics in obsessive-compulsive disorder.Psychiatry and clinical neurosciences · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
Inhibition deficits constitute a core characteristic of obsessive-compulsive disorder (OCD). There is evidence in healthy individuals that transcranial direct current stimulation (tDCS) of the pre-supplementary motor area (pre-SMA) leads to a significantly improved inhibition performance. Against this background we investigated the effects of pre-SMA tDCS on inhibition performance and the underlying neural correlates in patients with OCD. Using a double-blind, randomized, sham-controlled, cross-over design (i.e., tDCS sham vs. tDCS stimulation) we investigated the effects of 2 mA anodal tDCS stimulation of the right pre-SMA in a sample of 47 OCD patients. The present study is, to our best knowledge, the first study applying concurrent tDCS-fMRI in patients with OCD. tDCS was applied using the MRI-compatible NeuroConn DC-Stimulator which allowed for a concurrent stimulation, while patients performed an inhibition (i.e., Stroop) task in a 3 T MRI. Imaging data were analysed using a multivariate partial least squares (PLS) approach. tDCS stimulation (vs. sham) was associated with increased activation in a fronto-parieto-cerebellar network comprising, amongst others, the precentral, middle frontal and inferior frontal gyrus, the anterior cingulate and the superior parietal lobe. On the performance level, tDCS stimulation (vs. sham) was linked to an improved inhibition performance in terms of an increased percentage of correct responses in the Stroop task. Present results indicate that tDCS in patients with OCD goes along with an improved inhibition performance as well as activation increases in regions known to be involved in inhibition, motor, and cognitive control. Thus, our findings suggest that tDCS might be a promising method to improve specific impairments in OCD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.