Evidence map›Paper›PMID 40389269›Full record

ArticleAJNR. American journal of neuroradiology2025

The Cortical Vein Opacification Score Is Independently Associated with Good and Excellent Functional Outcomes at 90 Days in Patients with Minor Stroke with Anterior Circulation Large-Vessel Occlusion: A Multicenter Study.

Dhairya A Lakhani, Hamza Salim, Aneri B Balar, Subtain Ali, Sijin Wen, Janet Mei, Argye E Hillis, Victor C Urrutia, Risheng Xu, Gabriel Broocks and 10 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Dhairya A LakhaniFrom the Department of Neuroradiology (D.A.L., H.S., A.B.B., S.A.), Rockefeller Neuroscience Institute, West Virginia University, Morgantown, West Virginia dhairyalakhani@gmail.com.ORCID https://orcid.org/0000-0001-7577-1887
Hamza SalimFrom the Department of Neuroradiology (D.A.L., H.S., A.B.B., S.A.), Rockefeller Neuroscience Institute, West Virginia University, Morgantown, West Virginia.ORCID https://orcid.org/0000-0002-5208-8425
Aneri B BalarFrom the Department of Neuroradiology (D.A.L., H.S., A.B.B., S.A.), Rockefeller Neuroscience Institute, West Virginia University, Morgantown, West Virginia.ORCID https://orcid.org/0000-0002-3592-708X
Subtain AliFrom the Department of Neuroradiology (D.A.L., H.S., A.B.B., S.A.), Rockefeller Neuroscience Institute, West Virginia University, Morgantown, West Virginia.ORCID https://orcid.org/0000-0002-9522-9881
Sijin WenDepartment of Epidemiology and Biostatistics (S.W.), West Virginia University School of Public Health, Morgantown, West Virginia.
Janet MeiThe Russell H. Morgan Department of Radiology and Radiological Science (D.A.L., J.M., V.S.Y.), Johns Hopkins University, Baltimore, Maryland.
Argye E HillisDepartments of Neurology (A.E.H.), Johns Hopkins University School of Medicine, Baltimore, Maryland.
Victor C UrrutiaDepartment of Neurosurgery (V.C.U., R.X.), Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID https://orcid.org/0000-0002-4995-6949
Risheng XuDepartment of Neurosurgery (V.C.U., R.X.), Johns Hopkins University School of Medicine, Baltimore, Maryland.
Gabriel BroocksDepartment of Diagnostic and Interventional Neuroradiology (G.B.), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID https://orcid.org/0000-0002-7575-9850
Jens FiehlerDepartment of Radiology, Neuroendovascular Program (J.F., H.C.K.), University Medical Center Hamburg, Hamburg, Germany.ORCID https://orcid.org/0000-0001-8533-7478
Helge C KniepDepartment of Radiology, Neuroendovascular Program (J.F., H.C.K.), University Medical Center Hamburg, Hamburg, Germany.ORCID https://orcid.org/0000-0001-5258-2370
Paul StrackeDepartment of Radiology, Neuroendovascular Program (P.S., H.K.), University Medical Center Münster, Münster, Münster, Germany.
Hermann KrählingDepartment of Radiology, Neuroendovascular Program (P.S., H.K.), University Medical Center Münster, Münster, Münster, Germany.
Gregory W AlbersDepartment of Neurology (G.W.A., M.L.), Stanford University, Stanford, California.
Maarten LansbergDepartment of Neurology (G.W.A., M.L.), Stanford University, Stanford, California.ORCID https://orcid.org/0000-0002-3545-6927
Max WintermarkDepartment of Neuroradiology (M.W.), MD Anderson Medical Center, Houston, Texas.ORCID https://orcid.org/0000-0002-6726-3951
Jeremy J HeitDepartment of Radiology (J.J.H.), Division of Neuroadiology and Neurointervention, Stanford University, Stanford, California.ORCID https://orcid.org/0000-0003-1055-8000
Tobias D FaizyDepartment of Radiology (T.D.F.), Neuroendovascular Division, University Medical Center Münster, Germany.
Vivek S YedavalliThe Russell H. Morgan Department of Radiology and Radiological Science (D.A.L., J.M., V.S.Y.), Johns Hopkins University, Baltimore, Maryland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThere is currently no consensus on the most appropriate emergent treatment for patients with acute ischemic stroke secondary to large-vessel occlusion and minor stroke. These patients were excluded from prior randomized controlled trials assessing the efficacy of mechanical thrombectomy in large-vessel occlusion, making it challenging to determine the best treatment approach. Therefore, identifying markers that can predict functional outcomes would be invaluable for triaging these patients for mechanical thrombectomy. This study aimed to investigate pretreatment clinical and imaging markers and their association with functional outcomes at 90 days in patients with minor acute ischemic stroke secondary to large-vessel occlusion (AIS-LVO). MATERIALS AND

methodsWe included patients with AIS-LVO and minor strokes from 4 sites across North America and Europe. Minor stroke was defined as a baseline NIHSS score of ≤5. The primary outcome measure, good functional outcome, was defined as an mRS score of 0-2 at 90 days. The secondary outcome, excellent functional outcome, was defined as an mRS score of 0-1 at 90 days. Univariable and multivariable logistic regression analyses, along with receiver operating characteristic curve analysis, were performed.

resultsAmong 168 consecutive patients with minor strokes, 123 achieved a good functional outcome, and 103 patients had an excellent functional outcome at 90 days. The cortical vein opacification score (COVES) was independently associated with both excellent and good functional outcomes, whereas no other CT, CTA, or CTP markers showed a significant association with these outcomes. Receiver operating characteristic analysis of COVES showed an area under the curve of 0.638 (95% CI, 0.517-0.759;

conclusionsOur analysis demonstrates that COVES is independently associated with good and excellent functional outcomes at 90 days in cases of minor AIS-LVO. Further prospective studies are needed to better understand the role of COVES in determining optimal management strategies for these patients.

Indexed as

Cerebral VeinsIschemic StrokeAgedAged, 80 and overFemaleHumansMaleMiddle AgedThrombectomyTreatment Outcome

Identifiers

PMID40389269
PMCPMC12453510

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.