Evidence map›Paper›PMID 40389238›Full record

ReviewCell proliferation2025

Engineering Intervertebral Disc Regeneration: Biomaterials, Cell Sources and Animal Models.

Sidong Yang, Farhad Soheilmoghaddam, Peter Pivonka, Joan Li, Samuel Rudd, Trifanny Yeo, Ji Tu, Yibo Zhu, Justin J Cooper-White

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell proliferation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sidong YangTissue Engineering and Microfluidics Laboratory (TE&M), Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, St Lucia, Queensland, Australia.ORCID https://orcid.org/0000-0003-2342-4714
Farhad SoheilmoghaddamTissue Engineering and Microfluidics Laboratory (TE&M), Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, St Lucia, Queensland, Australia.
Peter PivonkaSchool of Mechanical Medical & Process Engineering, Queensland University of Technology, Brisbane City, Queensland, Australia.
Joan LiFaculty of Medicine, The University of Queensland, St Lucia, Queensland, Australia.
Samuel RuddSchool of Chemical Engineering, The University of Queensland, St Lucia, Queensland, Australia.
Trifanny YeoTissue Engineering and Microfluidics Laboratory (TE&M), Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, St Lucia, Queensland, Australia.
Ji TuSpine Labs, St. George & Sutherland Clinical School, University of New South Wales, Sydney, New South Wales, Australia.
Yibo ZhuSchool of Chemical Engineering, The University of Queensland, St Lucia, Queensland, Australia.
Justin J Cooper-WhiteTissue Engineering and Microfluidics Laboratory (TE&M), Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, St Lucia, Queensland, Australia.

Funding

Twin Towns Services Community Foundation Limited
6 · The paper itself

Abstract

Intervertebral disc (IVD) degeneration is an age-related problem triggering chronic spinal issues, such as low back pain and IVD herniation. Standard surgical treatment for such spinal issues is the removal of the degenerated or herniated IVD and fusion of adjacent vertebrae to stabilise the joint and locally decompress the spinal cord and/or nerve roots to relieve pain. However, a key challenge of current surgical strategies is the increasing risk of adjacent segment degeneration due to the disruption of native biomechanics of the functional spinal unit, dominated by the loss of the IVD. In the past two decades, research has focused on developing a number of bioengineering approaches to repair and regenerate the IVD; in particular, tissue engineering of the IVD, using bioscaffolds and stem cells represents a promising area. This review highlights the current tissue engineering approaches utilising biomaterials, animal models and cell sources for IVD regeneration and discusses future opportunities.

Indexed as

Biocompatible MaterialsIntervertebral DiscIntervertebral Disc DegenerationRegenerationTissue EngineeringAnimalsDisease Models, AnimalHumansStem CellsTissue ScaffoldsBiocompatible Materialsbiomaterialsintervertebral disc degenerationIVD regenerationspinestem cellstissue engineering

Identifiers

PMID40389238
PMCPMC12414645

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.