Evidence map›Paper›PMID 40388646›Full record

ArticleACS chemical biology2025

Human PTGR2 Inactivation Alters Eicosanoid Metabolism and Cytokine Response of Inflammatory Macrophages.

Michael W Founds, Olivia L Murtagh, R Justin Grams, Zhihong Li, Anthony M Ciancone, Robert J Seal, Ku-Lung Hsu

Abstract read
In one paragraph

Article in ACS chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michael W FoundsDepartment of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.
Olivia L MurtaghDepartment of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.
R Justin GramsDepartment of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.
Zhihong LiDepartment of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.
Anthony M CianconeDepartment of Chemistry, University of Virginia, Charlottesville, Virginia 22904, United States.
Robert J SealDepartment of Chemistry, University of Virginia, Charlottesville, Virginia 22904, United States.
Ku-Lung HsuDepartment of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0001-5620-3972

Funding

Endocannabinoid Biosynthesis in Inflammation and PainR01DA043571 · NIDA · UNIVERSITY OF VIRGINIA · PI Ku-Lung Hsu · 2017 to 2026
$3.5M
Defining and targeting substrate specificity of protein tyrosine phosphatasesR01GM144472 · NIGMS · UNIVERSITY OF VIRGINIA · PI HSU, KU-LUNG · 2022 to 2025
$1.6M
Chemical proteomic investigation of lipid kinase specificity and druggabilityR01AI169412 · NIAID · UNIVERSITY OF VIRGINIA · PI Ku-Lung Hsu · 2023 to 2026
$1.5M
NIAID NIH HHS R01 AI169412NIDA NIH HHS R01 DA043571NIGMS NIH HHS R01 GM144472
6 · The paper itself

Abstract

Prostaglandin reductase 2 (PTGR2) regulates inflammatory lipid signaling through the metabolism of the PGE2 metabolite 15-keto-PGE

Indexed as

CytokinesEicosanoidsMacrophagesTriazolesHumansInflammationLigandsLipopolysaccharidesTHP-1 CellsCytokinesEicosanoidsLigandsLipopolysaccharidesTriazoles

Identifiers

PMID40388646
PMCPMC12710877

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.