Evidence map›Paper›PMID 40388616›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Physical activity stimulates clock neurons of the day-active rodent

Rosanna Caputo, Robin A Schoonderwoerd, Ashna Ramkisoensing, Jan A M Janse, Hester C van Diepen, Sylvie Raison, Paul Pévet, Dominique Sage-Ciocca, Tom Deboer, Etienne Challet and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Physical activity stimulates clock neurons of the day-active rodentProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rosanna Caputo *Department of Cell and Chemical Biology, Laboratory for Neurophysiology, Leiden University Medical Center, Leiden 2300, The Netherlands.
Robin A Schoonderwoerd *Department of Cell and Chemical Biology, Laboratory for Neurophysiology, Leiden University Medical Center, Leiden 2300, The Netherlands.ORCID 0000-0001-9702-2094
Ashna RamkisoensingDepartment of Cell and Chemical Biology, Laboratory for Neurophysiology, Leiden University Medical Center, Leiden 2300, The Netherlands.
Jan A M JanseDepartment of Cell and Chemical Biology, Laboratory for Neurophysiology, Leiden University Medical Center, Leiden 2300, The Netherlands.ORCID 0000-0002-9632-993X
Hester C van DiepenDepartment of Cell and Chemical Biology, Laboratory for Neurophysiology, Leiden University Medical Center, Leiden 2300, The Netherlands.
Sylvie RaisonInstitute of Cellular and Integrative Neurosciences, CNRS, Laboratory of Circadian Clocks and Metabolism, University of Strasbourg, Strasbourg 67000, France.ORCID 0000-0003-0977-5315
Paul PévetInstitute of Cellular and Integrative Neurosciences, CNRS, Laboratory of Circadian Clocks and Metabolism, University of Strasbourg, Strasbourg 67000, France.
Dominique Sage-CioccaChronobiotron, UAR3415, CNRS, University of Strasbourg, Strasbourg 67000, France.
Tom DeboerDepartment of Cell and Chemical Biology, Laboratory for Neurophysiology, Leiden University Medical Center, Leiden 2300, The Netherlands.ORCID 0000-0002-6402-6248
Etienne ChalletInstitute of Cellular and Integrative Neurosciences, CNRS, Laboratory of Circadian Clocks and Metabolism, University of Strasbourg, Strasbourg 67000, France.ORCID 0000-0001-9416-9496
Johanna H MeijerDepartment of Cell and Chemical Biology, Laboratory for Neurophysiology, Leiden University Medical Center, Leiden 2300, The Netherlands.ORCID 0000-0001-6619-5312

Funding

EC | ERC | HORIZON EUROPE European Research Council (ERC) 834513IDEX-Unistra ANR-10-IDEX-0002-02NWO 645.000.010Velux Stiftung foundation 1131
6 · The paper itself

Abstract

Our biological clock, located in the suprachiasmatic nucleus (SCN), controls behavioral activity rhythms by producing circadian rhythms in SCN electrical activity. Behavioral studies in humans suggest that the clock is sensitive not only to light but also to physical activity. Here, we examined the effect of physical activity on the brain's clock in the diurnal rodent,

Indexed as

Biological ClocksCircadian RhythmMotor ActivityNeuronsPhysical Conditioning, AnimalSuprachiasmatic NucleusAnimalsBehavior, AnimalMalediurnalityexercisein vivo electrophysiologySudanian grass ratsuprachiasmatic nucleus

Identifiers

PMID40388616
PMCPMC12130842

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.