Evidence map›Paper›PMID 40388608›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Identification of the lydiamycin biosynthetic gene cluster in a plant pathogen guides structural revision and identification of molecular target.

Jonathan J Ford, Javier Santos-Aberturas, Edward S Hems, Joseph W Sallmen, Lena A K Bögeholz, Guy Polturak, Anne Osbourn, Joseph A Wright, Marina V Rodnina, Danny Vereecke and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jonathan J FordDepartment of Molecular Microbiology, John Innes Centre, Norwich NR4 7UH, United Kingdom.ORCID 0000-0001-9886-690X
Javier Santos-AberturasDepartment of Molecular Microbiology, John Innes Centre, Norwich NR4 7UH, United Kingdom.ORCID 0000-0002-6689-8111
Edward S HemsDepartment of Molecular Microbiology, John Innes Centre, Norwich NR4 7UH, United Kingdom.ORCID 0000-0002-5390-6020
Joseph W SallmenDepartment of Molecular Microbiology, John Innes Centre, Norwich NR4 7UH, United Kingdom.ORCID 0000-0002-5041-299X
Lena A K BögeholzDepartment of Physical Biochemistry, Max Planck Institute for Multidisciplinary Sciences, Göttingen 37077, Germany.ORCID 0009-0001-1049-4556
Guy PolturakDepartment of Biochemistry and Metabolism, John Innes Centre, Norwich NR4 7UH, United Kingdom.ORCID 0000-0001-6317-7266
Anne OsbournDepartment of Biochemistry and Metabolism, John Innes Centre, Norwich NR4 7UH, United Kingdom.ORCID 0000-0003-2195-5810
Joseph A WrightSchool of Chemistry, University of East Anglia, Norwich NR4 7TJ, United Kingdom.ORCID 0000-0001-9603-1001
Marina V RodninaDepartment of Physical Biochemistry, Max Planck Institute for Multidisciplinary Sciences, Göttingen 37077, Germany.ORCID 0000-0003-0105-3879
Danny VereeckeSchool of Nursing, Howest University of Applied Sciences, Bruges 8200, Belgium.ORCID 0000-0003-3706-780X
Isolde M FrancisDepartment of Biology, California State University, Bakersfield, CA 93311.ORCID 0000-0003-4326-5132
Andrew W TrumanDepartment of Molecular Microbiology, John Innes Centre, Norwich NR4 7UH, United Kingdom.ORCID 0000-0001-5453-7485

Funding

Diamond Light Source (Diamond) MX32728UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/M011216/1UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BBS/E/J/000PR9790UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/T015349/1UKRI | Biotechnology and Biological Sciences Research Council (BBSRC) BB/X01097X/1
6 · The paper itself

Abstract

The natural products actinonin and matlystatin feature an

Indexed as

Multigene FamilyAmidohydrolasesBacterial ProteinsBiosynthetic PathwaysHydroxamic AcidsPlant DiseasesactinoninAmidohydrolasesBacterial ProteinsHydroxamic Acidspeptide deformylaseantibioticsbiosynthesisnonribosomal peptidespeptide deformylaseRhodococcus

Identifiers

PMID40388608
PMCPMC12130866

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.