Evidence map›Paper›PMID 40388352›Full record

ArticleJournal of the American Chemical Society2025

A Designed Zn

A Katherine Hatstat, Rian Kormos, Vee Xu, Guoming Du, Lijun Liu, Shao-Qing Zhang, William F DeGrado

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

A Katherine HatstatDepartment of Pharmaceutical Chemistry, University of California, San Francisco, California 94158-9001, United States.ORCID 0000-0001-8231-1838
Rian KormosDepartment of Pharmaceutical Chemistry, University of California, San Francisco, California 94158-9001, United States.
Vee XuBiotechnology Program, City College of San Francisco, San Francisco, California 94112, United States.
Guoming DuShanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China.
Lijun LiuProtein Structure and X-ray Crystallography Laboratory, Structural Biology Center, University of Kansas, Lawrence, Kansas 66047, United States.
Shao-Qing ZhangShanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China.
William F DeGradoDepartment of Pharmaceutical Chemistry, University of California, San Francisco, California 94158-9001, United States.ORCID 0000-0003-4745-263X

Funding

Deciphering the relationship between structure, dynamics and function in helical bundle proteinsR35GM122603 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WILLIAM DEGRADO · 2017 to 2026
$7.1M
Revealing signal transduction mechanisms through protein designK99GM155611 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HATSTAT, ANNA KATHERINE · 2024 to 2025
$238k
A protein design- and structure-guided interrogation of signal transduction mechanismsF32GM147962 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HATSTAT, ANNA KATHERINE · 2022 to 2024
$126k
NIGMS NIH HHS F32 GM147962NIGMS NIH HHS K99 GM155611NIGMS NIH HHS R35 GM122603
6 · The paper itself

Abstract

Generating stimulus-responsive allosteric signaling

Indexed as

Histidine KinaseZincModels, MolecularProtein DomainsProtein EngineeringSignal TransductionHistidine KinaseZinc

Identifiers

PMID40388352
PMCPMC12316403

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.