Evidence map›Paper›PMID 40388294›Full record

ArticlePhysiological genomics2025

Genetic mapping of electrocardiographic parameters in BXD strains reveals Chromosome 3 loci to be associated with cardiac repolarization abnormalities.

Buyan-Ochir Orgil, Fuyi Xu, Ning Li, Akhilesh K Bajpai, Neely R Alberson, Jason N Johnson, Qingqing Gu, Glenn T Wetzel, Jeffrey A Towbin, Lu Lu and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Physiological genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Buyan-Ochir OrgilDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, United States.
Fuyi XuDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee, United States.ORCID 0000-0002-5952-5771
Ning LiDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, United States.ORCID 0000-0002-1642-2393
Akhilesh K BajpaiDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee, United States.
Neely R AlbersonDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, United States.
Jason N JohnsonDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, United States.
Qingqing GuDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee, United States.
Glenn T WetzelDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, United States.
Jeffrey A TowbinDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, United States.
Lu LuDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee, United States.
Enkhsaikhan PurevjavDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, United States.ORCID 0000-0001-6188-7176

Funding

Discovery of modifier genes in cardiomyopathyR01HL151438 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LU, LU, PUREVJAV, ENKHSAIKHAN · 2020 to 2023
$2.5M
Genetic Modulation of Hypertrophic Cardiomyopathy SeverityR01HL128350 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LU, LU, SUN, YAO · 2016 to 2019
$2.0M
NHLBI NIH HHS R01 HL128350NHLBI NIH HHS R01 HL151438
6 · The paper itself

Abstract

Risk factors for cardiac arrhythmias that can cause sudden death and heart failure include genetics, age, lifestyle, and other environmental factors. The study assessed electrocardiography (ECG) traits in BXD mice and explored associated quantitative trait loci (QTLs). Five-minute electrocardiograms were recorded in 44 BXD strains at 4-5 mo of age (

Indexed as

Arrhythmias, CardiacChromosome MappingElectrocardiographyQuantitative Trait LociAnimalsFemaleMaleMiceBXDcardiac repolarizationelectrocardiographyQTLsystems genetics analysis

Identifiers

PMID40388294

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.