Evidence map›Paper›PMID 40388211›Full record

ArticleeLife2025

Viral-mediated Pou5f1 (Oct4) overexpression and inhibition of Notch signaling synergistically induce neurogenic competence in mammalian Müller glia.

Nguyet Le, Sherine Awad, Isabella Palazzo, Thanh Hoang, Seth Blackshaw

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Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Nguyet LeDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.
Sherine AwadDepartment of Ophthalmology and Visual Sciences, University of Michigan School of Medicine, Ann Arbor, United States.ORCID https://orcid.org/0000-0002-8606-0674
Isabella PalazzoDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.
Thanh HoangDepartment of Ophthalmology and Visual Sciences, University of Michigan School of Medicine, Ann Arbor, United States.
Seth BlackshawDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID https://orcid.org/0000-0002-1338-8476

Funding

Transcriptional regulation of retinal cell differentiation and functionR01EY020560 · NEI · JOHNS HOPKINS UNIVERSITY · PI BLACKSHAW, SETH · 2011 to 2021
$4.4M
Identification of gene regulatory networks that control proliferative and neurogenic competence in mammalian Müller gliaR01EY031685 · NEI · JOHNS HOPKINS UNIVERSITY · PI BLACKSHAW, SETH · 2020 to 2023
$2.0M
Identification of gene regulatory networks controlling temporal patterning in retinal progenitor cells and neurogenic Müller gliaR01EY036173 · NEI · JOHNS HOPKINS UNIVERSITY · PI Seth Blackshaw · 2024 to 2026
$2.0M
Alcon Research Institute Young Investigator AwardNEI NIH HHS R01 EY020560NEI NIH HHS R01 EY031685NEI NIH HHS R01EY031685NEI NIH HHS R01 EY036173Research to Prevent Blindness Stein Innovation Award
6 · The paper itself

Abstract

Retinal Müller glia in cold-blooded vertebrates can reprogram into neurogenic progenitors to replace neurons lost to injury, but mammals lack this ability. While recent studies have shown that transgenic overexpression of neurogenic bHLH factors and glial-specific disruption of NFI family transcription factors and Notch signaling induce neurogenic competence in mammalian Müller glia, induction of neurogenesis in wildtype glia has thus far proven elusive. Here, we report that viral-mediated overexpression of the pluripotency factor

Indexed as

Ependymoglial CellsNeurogenesisNeurogliaOctamer Transcription Factor-3Receptors, NotchSignal TransductionAnimalsKruppel-Like Factor 4MiceKlf4 protein, mouseKruppel-Like Factor 4Octamer Transcription Factor-3Pou5f1 protein, mouseReceptors, Notchglial cellmouseneurogenesisneurosciencepluripotencyreprogrammingretinal cell lineagesretinal development

Identifiers

PMID40388211
PMCPMC12088672

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.