ArticleDiabetes care2025
In Utero Exposure to Maternal Hyperglycemia and Offspring Type 2 Diabetes Genetic Risk Score Are Independently Associated With Risk of Impaired Glucose Tolerance in Youth.
Article in Diabetes care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- How the First 9 Months Shape the Rest of Your Life: The Impact of Gestational Diabetes on the Metabolic Future.Diabetes, obesity & metabolism · 2026Review
- A three-metabolite microbiota-associated signature for early risk stratification of gestational diabetes mellitus.Cardiovascular diabetology · 2026Article
- Type 2 diabetes prevention across the life course.Nature medicine · 2026Review
- Gestational glycaemia reflects lifelong glycaemia: the Pune Maternal Nutrition Study.Diabetologia · 2026Article
- Diabetes Fact Sheet 2025: Special Edition on Diabetes with Obesity and in Pregnancy.Diabetes & metabolism journal · 2026Article
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7 authors.
Funding
Abstract
objectiveWe tested associations of type 2 diabetes genetic risk score (T2D-GRS) and exposure to maternal hyperglycemia with childhood impaired glucose tolerance (IGT) and T2D and glycemic outcomes in youth from the Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study. RESEARCH DESIGN AND
methodsWe calculated T2D-GRS using 1,150 known genetic variants associated with T2D in adults. In utero exposures included gestational diabetes mellitus (GDM) and sum-of-glucose z scores during oral glucose tolerance test at ∼28 weeks' gestation. IGT + T2D and continuous glycemic outcomes were measured when children were 10-14 years old.
resultsIn 3,444 children (mean age, 11.4 years), higher maternal sum-of-glucose z scores and child T2D-GRS were both associated with higher glucose levels. In children exposed to GDM and with T2D-GRS >75th percentile, 15.9% had IGT + T2D, compared with 5.6% in nonexposed children.
conclusionsHigh genetic risk for diabetes and in utero exposure to maternal hyperglycemia are additively associated with IGT + T2D and glycemic outcomes in youth.
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