ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2025
Autonomic nervous system abnormalities in children with inflammatory bowel disease and irritable bowel syndrome: a comparative study.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Psychological Traits and Social Factors Associated with Irritable Bowel Syndrome in Children.Children (Basel, Switzerland) · 2026Article
- Sudoscan® and QSART in the composite autonomic severity scale: complementary approaches to sudomotor assessment in multiple sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Dietary Behaviors, Digestive Symptoms, and Neurovegetative Features in Disorders of Gut-Brain Interaction: A Cross-Sectional Clinical Study.Nutrients · 2026Article
- Paternal separation as an independent risk factor for irritable bowel syndrome in rural Chinese left-behind children: a multicenter cross-sectional study.Frontiers in public health · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
objectivesThis study aimed to investigate the subjective and objective autonomic nervous system (ANS) abnormalities in children with inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) compared with healthy children (HC).
methodsIn total, 69 children were enrolled: 23 in the IBD, 28 in the IBS, and 18 HC group. ANS symptoms were evaluated using the Composite Autonomic Symptom Score (COMPASS-31). The severity and distribution of ANS function were quantitated using adrenergic, cardiovagal, and sudomotor indices of the Composite Autonomic Severity Scale (CASS). Health-related quality of life (HRQoL) was assessed with the Pediatric Quality of Life Inventory (PedsQL).
resultsChildren with IBS scored highest on the COMPASS-31, followed by patients with IBD and HC (median 11.5, 6.3, and 1.7, respectively; p = 0.001). There was no significant difference between groups in CASS (p = 0.09); however, children with IBD had a higher score on the sudomotor index (p = 0.012). There was a significant difference in symptomatic autonomic dysfunction (defined as COMPASS-31 > 7.913 and CASS > 0) between children with IBS (61.5%) compared with children with IBD (42.1%) and HC (7.1%), p = 0.004. In multivariable logistic regression, the number of squats decreased the probability of special health care needs by 17.2%, and the presence of symptomatic autonomic dysfunction increased the probability by 515.4%.
conclusionsThe ANS is frequently affected in children with IBD and IBS; children with IBS show greater autonomic symptom burden, while children with IBD have greater sudomotor dysfunction. HRQoL is significantly influenced by observed ANS changes in both groups.
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