Evidence map›Paper›PMID 40387918›Full record

ArticlePediatric nephrology (Berlin, Germany)2026

Ambulatory blood pressure variability in prediction of target organ injury: the SHIP AHOY study.

Coral D Hanevold, Jang Dong Seo, Stephen R Daniels, Bonita E Falkner, Michael A Ferguson, Joseph T Flynn, Julie R Ingelfinger, Philip R Khoury, Marc B Lande, Kevin E Meyers and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Hypertension: Evaluation and Management.Indian journal of pediatrics · 2026
    Review
  5. Article
  6. Observational
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Coral D HanevoldDivision of Nephrology, Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA. coral.hanevold@gmail.com.ORCID http://orcid.org/0000-0002-2795-1530
Jang Dong SeoThe Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Stephen R DanielsChildren's Hospital Colorado, University of Colorado School of Medicine, Denver, CO, USA.
Bonita E FalknerThomas Jefferson University, Philadelphia, PA, USA.
Michael A FergusonDivision of Nephrology, Department of Pediatrics, Harvard Medical School, Boston Children's Hospital, Boston, MA, USA.
Joseph T FlynnDivision of Nephrology, Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.
Julie R IngelfingerDepartment of Pediatrics, Harvard Medical School, Boston, MA, USA.
Philip R KhouryTulane University, New Orleans, LA, USA.
Marc B LandeDepartment of Pediatrics, University of Rochester Medical Center, Rochester, NY, USA.
Kevin E MeyersDivision of Nephrology, Perelman School of Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.
Mark MitsnefesCincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA.
Joshua SamuelsDivision of Pediatric Nephrology and Hypertension, McGovern Medical School at the University of Texas-Houston, Houston, TX, USA.
Elaine M UrbinaCincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA.

Funding

Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0M
LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI MEINZEN-DERR, JAREEN, STRAWN, JEFFREY ROBERT · 2015 to 2024
$37.5M
The University of Rochester's Clinical and Translational Science InstituteUL1TR002001 · NCATS · UNIVERSITY OF ROCHESTER · PI WILSON, KAREN M., ZAND, MARTIN S · 2016 to 2024
$34.6M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6M
American Heart Association 15SFRN23680000NCATS NIH HHS UL1 TR001425NCATS NIH HHS UL1 TR002001NCATS NIH HHS UL1 TR002319NIDDK NIH HHS P30 DK048520NIDDK NIH HHS UL1 TR002001NIDDK NIH HHS UL1 TR002319NIDDK NIH HHS UR1 TR001425
6 · The paper itself

Abstract

backgroundAmbulatory hypertension is associated with elevated left ventricular mass index (LVMI), cardiac dysfunction, and increased arterial stiffness in adolescents. Whether the addition of measures of BP variability improves the prediction of subclinical cardiovascular target organ damage (TOD) over mean BP measures is not known.

methodsWe assessed clinic and ambulatory BP (ABP), anthropometrics, and TOD in 397 adolescents. ABP means standard deviation (SD), BP, and heart rate (HR) dipping were calculated; coefficients of variability (CV) were calculated (SD/mean) to assess ABP variabilities. Measures of TOD included LVMI, left ventricular hypertrophy (LVH), LV systolic shortening, LV diastolic function (e'/a'), and pulse wave velocity. General linear models were used to determine if increased ABP variability measures were significant determinants of TOD in models containing mean ABP percentiles, age, sex, race/ethnicity, BMI z-score, and HR.

resultsMean participant age was 15.6 ± 1.7 years (63% white, 59% male) with mean casual BP 122.6/71.6 mmHg ±12.4/10.5, and mean awake systolic ABP 124.2/72.0 ± 11.3/7.7 mmHg. In linear models, increased awake CV-DBP and HR dipping were significant determinants of LVMI. CV-HR was an independent determinant of diastolic (e'/a') but not systolic dysfunction. Using logistic regression, the combination of awake and asleep diastolic ABP variability and awake systolic ABP percentile improved the prediction of LVH.

conclusionsConsideration of ABP variability in addition to ABP percentile may aid in identifying adolescents at risk for LVH.

Indexed as

Blood PressureBlood Pressure Monitoring, AmbulatoryHypertensionHypertrophy, Left VentricularAdolescentFemaleHeart RateHumansMalePulse Wave AnalysisRisk FactorsVascular StiffnessBlood pressureBlood pressure variabilityDiastolic dysfunctionHeart rate variabilityLeft ventricular hypertrophy

Identifiers

PMID40387918
PMCPMC12416511

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.