Evidence map›Paper›PMID 40387892›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2025

Safety and efficacy of amiodarone and dronedarone for early rhythm control in EAST-AFNET 4.

Laura Rottner, Marc D Lemoine, Lars Eckardt, Katrin Borof, A John Camm, Andreas Goette, Günter Breithardt, Andreas Metzner, Ulrich Schotten, Antonia Zapf and 8 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01288352 (Early Therapy of Atrial Fibrillation for Stroke Prevention Trial), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01288352 phase4completednot on this map

Early Therapy of Atrial Fibrillation for Stroke Prevention Trial (EAST).

TypeinterventionalSponsorAtrial Fibrillation NetworkRan2011 to 2020Enrolled2,789ConditionsAtrial Fibrillation, StrokeArmsearly standardised rhythm control
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Interactions of blood biomolecules with early rhythm control in atrial fibrillation patients: exploratory analysis of the EAST-AFNET 4 biomolecule study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Trial
  2. Transforming atrial fibrillation management by targeting comorbidities and reducing atrial fibrillation burden: the 10th AFNET/EHRA consensus conference.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Laura Rottner *Department of Cardiology, University Heart and Vascular Center UKE Hamburg, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany. l.rottner@uke.de.
Marc D Lemoine *Department of Cardiology, University Heart and Vascular Center UKE Hamburg, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Lars EckardtAtrial Fibrillation Network (AFNET), Münster, Germany.
Katrin BorofDepartment of Cardiology, University Heart and Vascular Center UKE Hamburg, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
A John CammCardiology Clinical Academic Group, Molecular and Clinical Sciences Research Institute, St. George's University of London, London, UK.
Andreas GoetteAtrial Fibrillation Network (AFNET), Münster, Germany.
Günter BreithardtAtrial Fibrillation Network (AFNET), Münster, Germany.
Andreas MetznerDepartment of Cardiology, University Heart and Vascular Center UKE Hamburg, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Ulrich SchottenAtrial Fibrillation Network (AFNET), Münster, Germany.
Antonia ZapfInstitute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hein HeidbüchelAtrial Fibrillation Network (AFNET), Münster, Germany.
Stephan WillemsDepartment of Cardiology, St. Georg Hospital Hamburg, Hamburg, Germany.
Harry CrijnsDepartment of Cardiology, Maastricht University Medical Center and Cardiovascular Research Institute, Maastricht, Netherlands.
Renate B SchnabelDepartment of Cardiology, University Heart and Vascular Center UKE Hamburg, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Larissa FabritzDepartment of Cardiology, University Heart and Vascular Center UKE Hamburg, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Christina MagnussenDepartment of Cardiology, University Heart and Vascular Center UKE Hamburg, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Andreas RilligDepartment of Cardiology, University Heart and Vascular Center UKE Hamburg, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Paulus KirchhofDepartment of Cardiology, University Heart and Vascular Center UKE Hamburg, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsConcerns exist about the safety of amiodarone and dronedarone. We assessed the long-term outcome of both drugs for early rhythm control (ERC) in the EAST-AFNET 4 trial. METHODS AND

resultsPatients randomized for ERC and treated with amiodarone or dronedarone were compared to other ERC-therapies. Patients receiving amiodarone or dronedarone at initial therapy (n = 653/1395) were older with more comorbidities and less paroxysmal atrial fibrillation (AF, 29%) compared to patients never receiving amiodarone or dronedarone (Amiodarone/Dronedarone

conclusionEarly rhythm control using amiodarone or dronedarone rarely led to drug-related serious adverse events in EAST-AFNET 4. CLINICAL

trial registrationISRCTN04708680, NCT01288352, EudraCT2010-021258-20.

Indexed as

AmiodaroneAnti-arrhythmic drug therapyAtrial fibrillationDronedaroneSafety

Identifiers

PMID40387892

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.