ArticleJournal of applied physiology (Bethesda, Md. : 1985)2025
Impaired neurovascular coupling in metabolic syndrome: an fNIRS study.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- A pilot randomized controlled trial of the effects of dietary nitrate supplementation on dynamic cerebral autoregulation in older adults with metabolic syndrome.Physiological reports · 2026Trial
- Investigation of brain activation and functional connectivity characteristics following tennis-induced acute fatigue: evidence from fNIRS.European journal of applied physiology · 2026Article
- Cognitive-Enhancing Effects of Bioactive Compounds and Traditional Herbal Medicines in Elderly Patients with Metabolic Syndrome.Biomolecules · 2026Review
- Life-course body shape trajectories and cerebral oxygen metabolism in community-dwelling older adults.GeroScience · 2026Article
- Degree of rurality moderates the association of sedentary time with cognitive function in rural patients with cardiac diseases and depressive symptoms.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The mechanisms underpinning accelerated cognitive decline in metabolic syndrome (MetS) are poorly understood. Neurovascular coupling (NVC) is the coordinated matching of blood flow to neuronal activation and is dependent on endothelial function. NVC may drive blood flow dysregulation that contributes to neuronal damage and cognitive decline. The purpose was to assess NVC, peripheral endothelial function, and cognitive performance in older adults with MetS and healthy controls (CON), and the association of these factors. Older adults with and without MetS were recruited to complete a neurocognitive battery, assessment of NVC, and endothelial function. NVC was measured in the frontoparietal regions using functional near infrared spectroscopy (fNIRS) while participants completed the n-back task (0-, 1-, 2-back). Changes in oxyhemoglobin (HbO) and deoxyhemoglobin (HbR) signals reflected NVC during the n-back task. Endothelial function was measured using brachial ultrasound measurements of flow-mediated dilation (%FMD). MetS (
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