ArticleAmerican journal of physiology. Heart and circulatory physiology2025
The two-pore K
Abstract read
In one paragraph
Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Role for TREK-1 as a polymodal sensor and regulator of cell activity.Channels (Austin, Tex.) · 2026Review
- The βCirculation research · 2025Article
- TREK-1: a Janus-faced and subcellular location-based regulator of cardiac remodeling in heart failure.American journal of physiology. Heart and circulatory physiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Cemantha M L JohnsonFrick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States.ORCID 0000-0002-6571-9951
Drew M NassalFrick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States.ORCID 0000-0002-8018-3913
Alexander J WinkleFrick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States.ORCID 0000-0003-1226-2449
Benjamin BuckFrick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States.ORCID 0000-0002-6065-3885
Xianyao XuFrick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States.
Xiaoping WanFrick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States.
Mei HanFrick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States.
Simon LococoFrick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States.ORCID 0009-0001-9982-053X
Nicholas LeahyFrick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States.
Shivangi MohtaFrick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States.
Rebecca ShaheenFrick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States.
Omer CavusFrick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States.
Aaryan KohliFrick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States.
Yuanyuan CaoFrick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States.
Mona El RefaeyFrick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States.ORCID 0000-0003-3989-0920
Sakima SmithFrick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States.
Xun AiFrick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States.
Isabelle DeschênesFrick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States.ORCID 0000-0002-1812-7267
Thomas J HundFrick Center for Heart Failure and Arrhythmia, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, United States.ORCID 0000-0002-9957-7306
Funding
Distinct Ion Channel Pools and Intercalated Disk Nanoscale Structure Regulate Cardiac ConductionR01HL165751 · NHLBI · OHIO STATE UNIVERSITY · PI Thomas Jeffrey Hund, Rengasayee Veeraraghavan · 2023 to 2026
$2.9MNovel Roles of Protein phosphatase 2A in Cardiac ArrhythmiaR01HL175380 · NHLBI · OHIO STATE UNIVERSITY · PI Mona El Refaey · 2024 to 2026
$1.9MRole of TREK-1 in modulating cardiac excitability and arrhythmiaR01HL156652 · NHLBI · OHIO STATE UNIVERSITY · PI HUND, THOMAS JEFFREY · 2021 to 2024
$1.7MNovel role for the spectrin cytoskeleton in regulation of cardiac fibroblast activity, long-range communication and injury-induced fibrosisR01HL171689 · NHLBI · OHIO STATE UNIVERSITY · PI Thomas Jeffrey Hund · 2024 to 2026
$1.6MPostdoctoral Training in Cardiometabolic ScienceT32HL149637 · NHLBI · OHIO STATE UNIVERSITY · PI HSUEH, WILLA A, SMITH, SAKIMA AHMAD · 2020 to 2024
$1.5MRegulation of STAT3 phosphorylation and its role in orienting myocyte hypertrophyR00HL157684 · NHLBI · OHIO STATE UNIVERSITY · PI Drew Nassal · 2024 to 2026
$747kDefining new pathways for cardiac automaticityR00HL146969 · NHLBI · OHIO STATE UNIVERSITY · PI EL REFAEY, MONA · 2021 to 2023
$747kRegulation of STAT3 phosphorylation and its role in orienting myocyte hypertrophyK99HL157684 · NHLBI · OHIO STATE UNIVERSITY · PI NASSAL, DREW · 2022 to 2023
$224kStress-induced loss of BIV-spectrin regulates cardiac fibroblast function and long-range communicationF31HL170749 · NHLBI · OHIO STATE UNIVERSITY · PI SHAHEEN, REBECCA J. · 2023 to 2025
$132kInvolvement of TWIK-related K+ channel in cardiac disease and arrhythmiaF31HL162547 · NHLBI · OHIO STATE UNIVERSITY · PI JOHNSON, CEMANTHA ML · 2022 to 2023
$54kFondation Leducq (Leducq Foundation) TNE 19CVD03HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) F31HL162547HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) F31HL170749HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) K99HL157684HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL156652HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL165751HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL171689HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) T32HL149637NHLBI NIH HHS F31 HL162547NHLBI NIH HHS F31 HL170749NHLBI NIH HHS K99 HL157684NHLBI NIH HHS R00 HL146969NHLBI NIH HHS R00 HL157684NHLBI NIH HHS R01 HL156652NHLBI NIH HHS R01 HL165751NHLBI NIH HHS R01 HL171689NHLBI NIH HHS R01 HL175380NHLBI NIH HHS T32 HL149637Ohio State University (OSU) The JB Project
Abstract
Heart failure (HF) represents a major burden on the healthcare system, with patients with HF at increased risk for a host of comorbidities, including ventricular arrhythmias. Despite considerable advances in defining cell- and organ-level changes associated with HF, the precise mechanisms driving structural and electrical remodeling remain to be defined. We sought to elucidate the role of the two-pore K
Indexed as
Heart FailureHypertrophy, Left VentricularMyocytes, CardiacPotassium Channels, Tandem Pore DomainVentricular Function, LeftVentricular RemodelingAction PotentialsAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, KnockoutMyocardial ContractionPhosphorylationSTAT3 Transcription Factorpotassium channel protein TREK-1Potassium Channels, Tandem Pore DomainStat3 protein, mouseSTAT3 Transcription Factorarrhythmiaheart failurespectrinSTAT3TREK1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.