Evidence map›Paper›PMID 40387609›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Bimetallic Plasmonic Nanozyme-Based Microneedle for Synergistic Ferroptosis Therapy of Melanoma.

Wei Duan, Keying Xu, Yue Gao, Sheng Huang, Xueqian Xia, Xiang Liu, Shuangxue Pan, Chunpeng Jiao, Weijian Cheng, Yong Guo and 2 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wei DuanKey Laboratory of Elemene Class Anti-Cancer Chinese Medicines, School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, P. R. China.ORCID https://orcid.org/0000-0002-6609-1043
Keying XuKey Laboratory of Elemene Class Anti-Cancer Chinese Medicines, School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, P. R. China.
Yue GaoKey Laboratory of Elemene Class Anti-Cancer Chinese Medicines, School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, P. R. China.
Sheng HuangKey Laboratory of Elemene Class Anti-Cancer Chinese Medicines, School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, P. R. China.
Xueqian XiaKey Laboratory of Elemene Class Anti-Cancer Chinese Medicines, School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, P. R. China.
Xiang LiuKey Laboratory of Elemene Class Anti-Cancer Chinese Medicines, School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, P. R. China.
Shuangxue PanKey Laboratory of Elemene Class Anti-Cancer Chinese Medicines, School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, P. R. China.
Chunpeng JiaoCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, 266580, P. R. China.
Weijian ChengKey Laboratory of Elemene Class Anti-Cancer Chinese Medicines, School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, P. R. China.
Yong GuoKey Laboratory of Elemene Class Anti-Cancer Chinese Medicines, School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, P. R. China.
Jingwen ZhaoSchool of Chemistry and Chemical Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, P. R. China.
Jia-Wei ShenKey Laboratory of Elemene Class Anti-Cancer Chinese Medicines, School of Pharmacy, Hangzhou Normal University, Hangzhou, 311121, P. R. China.

Funding

Interdisciplinary Research Project of Hangzhou Normal University 2024JCXK02Medical Science and Technology Project of Zhejiang Province 2025KY179National Natural Science Foundation of China 32401103 22378090Visiting Scholar Fund of State Key Laboratory of Silicon and Advanced Semiconductor Materials SKL2024-01Zhejiang Provincial Natural Science Foundation of China LQN25H180009
6 · The paper itself

Abstract

Melanoma is the most common malignant skin tumor, characterized by complexity, invasiveness, and heterogeneity. Conventional therapies often yield poor outcomes, posing significant clinical challenges. Here, a microneedle (MN) patch that integrates nanozyme and traditional Chinese medicine (TCM) for ferroptosis pathway-dependent combined therapy of melanoma is designed. To amplify therapeutic activity, a novel Au@MoS

Indexed as

FerroptosisMelanomaSkin NeoplasmsAnimalsCell Line, TumorGoldHumansMedicine, Chinese TraditionalMiceNeedlesGoldbimetallic plasmonic nanozymeferroptosismelanoma treatmentmicroneedleβ‐ELE

Identifiers

PMID40387609
PMCPMC12376522

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.