Evidence map›Paper›PMID 40387573›Full record

ArticleImmunology2025

Antibiotic-Induced Dysbiosis of the Gut Microbiota Shifts Host Tryptophan Metabolism and Increases the Susceptibility of Mice to Pulmonary Infection With Pseudomonas aeruginosa.

Camila Bernardo de Brito, Raquel Duque do Nascimento Arifa, Rafael de Oliveira Bezerra, Carlos Eduardo Dias Igídio, Bárbara Maria de Amorim-Santos, Anna Clara Paiva de Menezes Santos, Larissa Mendes Barbosa, João Paulo Pezzini Barbosa, Larissa Marcely Gomes Cassiano, Markus Kohlhoff and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Camila Bernardo de BritoLaboratório de Interação Microrganismo-Hospedeiro, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Raquel Duque do Nascimento ArifaLaboratório de Interação Microrganismo-Hospedeiro, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Rafael de Oliveira BezerraLaboratório de Interação Microrganismo-Hospedeiro, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Carlos Eduardo Dias IgídioLaboratório de Interação Microrganismo-Hospedeiro, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Bárbara Maria de Amorim-SantosLaboratório de Interação Microrganismo-Hospedeiro, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Anna Clara Paiva de Menezes SantosLaboratório de Interação Microrganismo-Hospedeiro, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Larissa Mendes BarbosaLaboratório de Interação Microrganismo-Hospedeiro, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
João Paulo Pezzini BarbosaLaboratório de Interação Microrganismo-Hospedeiro, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Larissa Marcely Gomes CassianoInstituto René Rachou (IRR) - FIOCRUZ. FIOCRUZ MG, Belo Horizonte, MG, Brazil.
Markus KohlhoffInstituto René Rachou (IRR) - FIOCRUZ. FIOCRUZ MG, Belo Horizonte, MG, Brazil.
Micheli FagundesLaboratório de Interação Microrganismo-Hospedeiro, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Rafaela Ribeiro Álvares BatistaLaboratório de Interação Microrganismo-Hospedeiro, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Celso Martins Queiroz-JuniorCentro de Pesquisa e Desenvolvimento de Fármacos, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Alessandra M SalibaDepartamento de Microbiologia e Imunologia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.
Juliana Divina Almeida RaposoDepartamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Fernão Castro BragaDepartamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Roney Santos CoimbraInstituto René Rachou (IRR) - FIOCRUZ. FIOCRUZ MG, Belo Horizonte, MG, Brazil.ORCID 0000-0002-9204-0573
Mauro Martins TeixeiraCentro de Pesquisa e Desenvolvimento de Fármacos, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Caio Tavares FagundesLaboratório de Interação Microrganismo-Hospedeiro, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Danielle G SouzaLaboratório de Interação Microrganismo-Hospedeiro, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.ORCID 0000-0002-7478-5934

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 304490/2014-8Conselho Nacional de Desenvolvimento Científico e Tecnológico 421 465425/2014Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88882.348380/2010-1Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-00897-22Instituto Nacional de Ciencia e Tecnologia em Dengue- INCT Dengue
6 · The paper itself

Abstract

Pseudomonas aeruginosa is an opportunistic bacterium that mainly infects those who have previously been treated with antibiotics. We hypothesised that antibiotic treatment disrupts tryptophan metabolism, leading to increased susceptibility to P. aeruginosa infection. Our results showed that mice receiving antibiotics exhibited intestinal dysbiosis with alterations in host tryptophan metabolism, a higher mortality rate and a higher bacterial load compared to eubiotic mice. In the lungs of the dysbiotic mice, there was an increase in IDO1 (Indoleamine 2,3-dioxygenase 1) activity and an accumulation of kynurenine after infection, and IDO1

Indexed as

Anti-Bacterial AgentsDysbiosisGastrointestinal MicrobiomePseudomonas aeruginosaPseudomonas InfectionsTryptophanAnimalsDisease Models, AnimalDisease SusceptibilityIndoleamine-Pyrrole 2,3,-DioxygenaseKynurenineLungMacrophagesMaleMiceMice, Inbred C57BLAnti-Bacterial AgentsIDO1 protein, mouseIndoleamine-Pyrrole 2,3,-DioxygenaseKynurenineReceptors, Aryl HydrocarbonTryptophanAHR and Pseudomonas aeruginosaantibioticshost‐targeted therapyIDO1inflammationneutrophils

Identifiers

PMID40387573
PMCPMC12234421

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.