ArticleAIDS (London, England)2025
HIV-1 infection recency among individuals newly diagnosed with HIV in Greater Gaborone, Botswana.
Article in AIDS (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Recent HIV Infections in Italy: Data from the HIV National Surveillance System, 2012-2023.Pathogens (Basel, Switzerland) · 2025Article
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18 authors.
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Abstract
objectiveWe characterized individuals with HIV type 1 (HIV-1) recent infection using a two-step recent infection testing algorithm (RITA) in recently diagnosed, antiretroviral therapy (ART)-naive individuals within the Greater Gaborone area in Botswana.
designPlasma samples from a prospective longitudinal cohort study of individuals recently diagnosed with HIV within the Greater Gaborone area (2023-2024), the Tekodiso study, were used.
methodsRecent infection classification was determined using Limiting Antigen Avidity (LAg-avidity), as well as HIV viral load greater than 1000 copies/ml. LAg-normalized optical density (ODn) 1.5 or less represented a recency window of within 130 days postinfection. HIV viral load in plasma was quantified by Abbott m2000sp/Abbott m2000rt.
resultsA total of 157 participants were included in this analysis. Median age at enrolment was 34 years (Q1, Q3: 27, 41), and majority 102 (65%) were female. The median log 10 HIV viral load was 4.6 copies/ml (Q1, Q3: 3.9, 5.2). A total of 12 of 157: 7.6% [95% confidence interval (CI) 4.0-13] individuals were classified as having a recent infection. Recent infection was not associated with age, employment status, or nationality. We observed a lower likelihood of recent HIV infection with secondary or higher education level (OR = 0.1; 95% CI: 0.1- 0.9).
conclusionWe report a 7.6% rate of HIV recent infection by LAg-based RITA in recently diagnosed ART-naive individuals in Botswana. Our results highlight the need for continued HIV infection surveillance to improve targeted interventions for the prevention of HIV acquisition within the country.
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