ArticleMedical physics2025
Megavoltage photon FLASH for preclinical experiments.
Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Harnessing the sparing effect of FLASH-RT: From phenomenon observation, radiophysical determinants to molecular mechanisms and synergistic strategies.Materials today. Bio · 2026Review
- Conditional sparing in FLASH radiotherapy: Conformal dosimetry and ALARA remain essential.Journal of applied clinical medical physics · 2026Review
- FLASH Radiotherapy and Organelle-Targeted Radiosensitization in Glioblastoma: A Conceptual and Translational Review.Cancers · 2026Review
- A preclinical setup for spatially fractionated radiation therapy with electrons.Medical physics · 2026Article
- Quantifying the flash effect and its dependence on average dose rate in vivo for 6 MeV electron and 6 MV photon beams.Clinical and translational radiation oncology · 2026Article
- New modalities for ultra-high dose rate irradiation and FLASH experiments.Physics and imaging in radiation oncology · 2025Article
- Development and characterization of phantoms to investigate the Flash effect withPhysics and imaging in radiation oncology · 2025Article
- The impact of dose rate optimisation and robust optimisation on FLASH proton therapy treatment plan quality and dose rates.Frontiers in oncology · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundFLASH radiotherapy using megavoltage (MV) photon beams should enable greater therapeutic efficacy, target deep seated tumors, and provide insights into mechanisms within FLASH. PURPOSE: In this study, we aim to show how to facilitate ultra-high dose rates (FLASH) with MV photons over a field size of 12-15 mm, using a 6 MeV (nominal) preclinical electron linear accelerator (linac). Our intention is to utilize this setup to deliver FLASH with MV photons in future preclinical experiments.
methodsAn electron linear accelerator operating at a pulse repetition frequency of 300 Hz, a tungsten target, and a beam hardening filter were used, in conjunction with beam tuning and source-to-surface distance (SSD) reduction. Depth dose curves, beam profiles, and average dose rates were determined using EBT-XD Gafchromic film, and an Advanced Markus ionization chamber was used to measure the photon charge output.
resultsA 0.55 mm thick tungsten target, in combination with a 6 mm thick copper hardening filter were found to produce photon FLASH dose rates, with minimal electron contamination, delivering dose rates > 40 Gy/s over fields of 12-15 mm. Beam flatness and symmetry were comparable in horizontal and vertical planes.
conclusionUltra-high average dose rate beams have been achieved with MV photons for preclinical irradiation fields, enabling future preclinical FLASH radiation experiments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.