Evidence map›Paper›PMID 40387454›Full record

ArticleInfection and immunity2025

Maternal transfer of oral vaccine induced anti-OspA antibodies protects

Jose F Azevedo, Greg Joyner, Suman Kundu, Kamalika Samanta, Maria Gomes-Solecki

Abstract read
In one paragraph

Article in Infection and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Protective efficacy of mutant strains ofInfection and immunity · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Jose F AzevedoDepartment of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, USA
Greg JoynerDepartment of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, USAORCID 0000-0001-9333-6600
Suman KunduDepartment of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, USAORCID 0000-0002-8591-1166
Kamalika SamantaDepartment of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, USAORCID 0000-0002-8591-1166
Maria Gomes-SoleckiDepartment of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, USAORCID 0000-0002-3715-4543

Funding

Field trial and modeling of transmission blocking vaccine to prevent Lyme diseaseR01AI139267 · NIAID · UNIVERSITY OF IOWA · PI BROWN, GRANT D, GOMES-SOLECKI, MARIA · 2019 to 2023
$3.6M
Intranasal Vaccine Against Lyme DiseaseR44AI167605 · NIAID · IMMUNO TECHNOLOGIES, INC. · PI GOMES-SOLECKI, MARIA · 2022 to 2024
$3.0M
Antibody isotyping for discrimination of disease stage and diagnosis of early Lyme disease.R43AI155211 · NIAID · IMMUNO TECHNOLOGIES, INC. · PI GOMES-SOLECKI, MARIA · 2020 to 2021
$594k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI139267HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI139267,R44AI167605HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI139267,R44AI167605,R43AI155211HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R44AI167605NIAID NIH HHS R01 AI139267NIAID NIH HHS R43 AI155211NIAID NIH HHS R44 AI167605
6 · The paper itself

Abstract

The efficacy and duration of passive immunity protection depend on maternal antibody levels and transfer efficiency. We investigated whether oral vaccination of

Indexed as

Antibodies, BacterialAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial VaccinesBorrelia burgdorferiImmunity, Maternally-AcquiredLipoproteinsLyme DiseasePeromyscusAdministration, OralAnimalsFemaleImmunoglobulin GIxodesAntibodies, BacterialAntigens, SurfaceBacterial Outer Membrane ProteinsBacterial VaccinesImmunoglobulin GLipoproteinsOspA proteinBorrelia burgdorferienzootic cycleIxodes scapularisLyme diseasemouseOspAPeromyscusreservoir targeted oral vaccinetransmission blocking

Identifiers

PMID40387454
PMCPMC12150685

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.