ArticleJournal of cellular and molecular medicine2025
Magnolin Mitigates Skin Ageing Through the CXCL10/p38 Signalling Pathway.
Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Phenolic Compounds and Derivatives in Ruminant Meat and Milk: A Systematic Review.Journal of agricultural and food chemistry · 2025Pooled it
- Plant-Derived Senotherapeutics in Cellular Senescence: A Scoping Review of Preclinical Evidence, Mechanistic Pathways, and Metabolomic-Guided Discovery.International journal of molecular sciences · 2026Article
- Targeting druggable kinases in neuropathic pain.npj drug discovery · 2026Review
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Skin ageing accelerates systemic ageing and impairs the body's disease resistance. Inflammaging is a significant contributor to skin ageing. However, the mechanism by which inflammatory factors contribute to skin ageing remains unclear. We conducted screenings and identified CXC motif chemokine ligand 10 (CXCL10) as an inducer of skin ageing, which can be effectively inhibited by magnolin extracted from Magnolia biondii flower. Our results show that CXCL10 not only enhances beta-galactosidase (β-gal) activity but also upregulates the expression of p21/p16, along with matrix metalloproteinases (MMP1, MMP9 and MMP10), through activation of the C-X-C motif chemokine receptor 3 (CXCR3) in human primary fibroblasts. These findings suggest that CXCL10 drives skin ageing by inducing cellular senescence and extracellular matrix degradation. Importantly, treatment with magnolin significantly mitigates skin ageing phenotypes induced by CXCL10 via the p38 signalling pathway. Furthermore, our study demonstrates that magnolin significantly mitigates UV-induced skin ageing in ex vivo human skin samples as well as on human facial skin. This study provides insight into the role of chemokine CXCL10 in promoting inflammaging and proposes an innovative approach for preventing and treating skin ageing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.