Evidence map›Paper›PMID 40387388›Full record

Trial reportClinical and experimental dental research2025

Peri-Implant Diseases: Enhanced Antibacterial Photodynamic Therapy.

Hanna Lähteenmäki, Tommi Pätilä, Ismo T Räisänen, Rauni Kalliala, Timo Sorsa

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical and experimental dental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hanna LähteenmäkiDepartment of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Tommi PätiläDepartment of Pediatric Heart Surgery and Organ Transplantation, New Children's Hospital, Helsinki University, Helsinki, Finland.
Ismo T RäisänenDepartment of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0001-5821-5299
Rauni KallialaDepartment of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Timo SorsaDepartment of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Funding

The authors received no specific funding for this work.
6 · The paper itself

Abstract

objectivesThe number of dental implants is constantly on the rise, and inflammation of their surrounding tissues is an increasing problem. In this randomized controlled trial, we investigated the effects of antibacterial dual-light photodynamic therapy (aPDT) in peri-implant disease in reduction of inflammation in the peri-implant tissues. MATERIAL AND

methodsForty patients with newly diagnosed peri-implant disease were recruited. The diagnoses were established clinically and by radiological bone loss (RBL). Dual-light aPDT was provided by indocyanine green mouth rinsing and 50:50, 405 nm, and 810 nm light applicator. The treatment group (n = 20) was randomized to use aPDT treatment at home for 4 weeks. The treatment was carried out once daily for 2 weeks, then twice daily for the next 2 weeks. The control group (n = 20) continued enhanced self-care during the study period. Traditional measurement methods around the implant were measured at the beginning, at 2 weeks and at 4 weeks.

resultsDuring the study period, VPI decreased in both groups. In the treatment group BOP decreased from mean (SD) 4.7 ± 1.3 to 1.8 ± 1.6, p < 0.0001, but no change was observed in the control group (3.5 ± 2.3 to 3.0 ± 2.3, p = 0.39). In the aPDT treatment group aMMP-8 decreased from mean (SD) 100 ± 41 to 72 ± 38, p = 0.027, but not in the control group (86 ± 54 to 86 ± 60, p = 0.38).

conclusionsRegularly applied dual-light aPDT reduces inflammation in the dental implant adjacent tissues. Dual-light aPDT approach holds promise as an effective home care tool for implant patients.

Indexed as

Alveolar Bone LossAnti-Bacterial AgentsDental ImplantsPeri-ImplantitisPhotochemotherapyAdultAgedFemaleHumansIndocyanine GreenMaleMiddle AgedPhotosensitizing AgentsTreatment OutcomeAnti-Bacterial AgentsDental ImplantsIndocyanine GreenPhotosensitizing AgentsaMMP‐8antibacterial photodynamic therapyoral hygieneperi‐implant disease

Identifiers

PMID40387388
PMCPMC12086973

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.