Evidence map›Paper›PMID 40387381›Full record

Trial reportAmerican journal of respiratory and critical care medicine2025

Iloprost for the Treatment of Severe Septic Shock with Persistent Hypoperfusion: A Double-Blind, Randomized Controlled Trial.

Matthieu Legrand, Edouard Jullien, Antoine Kimmoun, Guillaume Geri, Hafid Ait-Oufella, Stanislas Abrard, Samuel Gaugain, Fanny Bounes, Philippe Guerci, Julien Pottecher and 18 more

Abstract readClinical Trial, Phase IIIMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of respiratory and critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Refractory septic shock: our updated pragmatic approach.Journal of anesthesia, analgesia and critical care · 2026
    Review
  5. GPCRs as key regulators in wound healing.Frontiers in cell and developmental biology · 2026
    Review
  6. Prostacyclin for Patients with Septic Shock: Promise, Progress, and Perspective.American journal of respiratory and critical care medicine · 2025
    Article
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors.

Matthieu LegrandDivision of Critical Care Medicine, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California.ORCID 0000-0001-9788-5316
Edouard JullienIntensive Care Unit, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris, Versailles Saint-Quentin-en-Yvelines University, Paris, France.
Antoine KimmounFrench Clinical Research Infrastructure Network Initiative-Cardio Renal Clinical Trialists Network, Nancy, France.ORCID 0000-0002-5443-2074
Guillaume GeriIntensive Care Unit, Private Hospital Ambroise Paré Hartmann, Neuilly-sur-Seine, France.
Hafid Ait-OufellaIntensive Care Unit, Saint-Antoine University Hospital, and.
Stanislas AbrardDepartment of Anesthesiology and Critical Care Medicine, Hospices Civils de Lyon, Edouard Herriot Hospital, Lyon, France.
Samuel GaugainDepartment of Anesthesia and Critical Care, Assistance Publique-Hôpitaux de Paris, Lariboisière Hospital, Paris, France.
Fanny BounesIntensive Care Unit, Rangueil University Hospital, Toulouse, France.
Philippe GuerciFrench Clinical Research Infrastructure Network Initiative-Cardio Renal Clinical Trialists Network, Nancy, France.
Julien PottecherAnesthesiology, Critical Care and Perioperative Medicine, Strasbourg University Hospital, Strasbourg, France.
Matthieu JammeIntensive Care Unit, Ouest Parisien Private Hospital, Ramsay Générale de Santé, Trappes, France.
Yves Poncelin de RaucourtIntensive Care Unit, Bourg-en-Bresse Hospital, Bourg-en-Bresse, France.
Damien BarraudIntensive Care Unit, Mercy Hospital, Metz-Thionville Hospital, Metz, France.
Jean-Michel ConstantinDepartment of Anesthesia and Critical Care, La Pitié-Salpétrière University Hospital, Assistance Publique-Hôpitaux de Paris, Sorbonne University, Paris, France.
William JuguetIntensive Care Unit, Avicenne Hospital, Assistance Publique-Hôpitaux de Paris, Bobigny University, Paris, France.
Sigismond LasockiDepartment of Anesthesia and Critical Care, Angers University Hospital, Angers, France.
Romain SonnevilleParis Cité University, Institut National de laSante et de la Recherche Medicale U1137, Paris, France.ORCID 0000-0003-0245-309X
Juliette AudibertIntensive Care Unit, Chartres Hospital, Chartres, France.
Gaëtan PlantefèveIntensive Care Unit, Argenteuil Hospital, Argenteuil, France.
Olivier EllrodtIntensive Care Unit, Melun Hospital, Melun, France.
Anne-Laure FedouIntensive Care Unit, Dupuytren University Hospital, Limoges, France.
Marc LeoneDepartment of Anesthesia and Critical Care, Hospital Nord, Marseille, France.
Laurent LefebvreIntensive Care Unit, Centre Hospitalier Intercommunal Aix-Pertuis, Aix-en-Provence, France.
Adrien AuvetIntensive Care Unit, Dax Hospital, Dax, France.
David ChenDivision of Critical Care Medicine, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California.
Eric VicautFrench Clinical Research Infrastructure Network Initiative-Cardio Renal Clinical Trialists Network, Nancy, France.
François DépretFrench Clinical Research Infrastructure Network Initiative-Cardio Renal Clinical Trialists Network, Nancy, France.
I-MICRO Trial Investigators

Funding

Division of Diabetes, Endocrinology, and Metabolic Diseases R01DK139484-01French Ministry of Health PHRC 2018NIGMS NIH HHS R01-GM151494-01
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

IloprostMultiple Organ FailureShock, SepticVasodilator AgentsAgedDouble-Blind MethodFemaleHumansInfusions, IntravenousMaleMiddle AgedOrgan Dysfunction ScoresTreatment OutcomeIloprostVasodilator Agentsmicrocirculationorgan failureprostacyclinsepsis

Identifiers

PMID40387381
PMCPMC12264687

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.