Evidence map›Paper›PMID 40387377›Full record

ArticlemBio2025

Nuanced differences in adenylate cyclase toxin production, acylation, and secretion may contribute to the evolution of virulence in

Alexa R Wolber, Liliana S McKay, Katlyn B Mote, Richard M Johnson, Carol S Inatsuka, Peggy A Cotter

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexa R WolberDepartment of Microbiology and Immunology, School of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA.
Liliana S McKayDepartment of Microbiology and Immunology, School of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA.
Katlyn B MoteDepartment of Microbiology and Immunology, School of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA.
Richard M JohnsonDepartment of Microbiology and Immunology, School of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA.
Carol S InatsukaDepartment of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, California, USA.
Peggy A CotterDepartment of Microbiology and Immunology, School of Medicine, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0003-3726-3990

Funding

Cooperative roles of FHA and ACT in Bordetella virulenceR01AI153160 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COTTER, PEGGY A · 2021 to 2025
$2.6M
PlrSR-dependent Signal Transduction in Bordetella VirulenceR01AI129541 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COTTER, PEGGY A · 2017 to 2021
$2.5M
Genetic Analysis of Bordetella PathogenesisR01AI043986 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COTTER, PEGGY A · 1999 to 2009
$2.3M
Function and Secretion of Bordetella Filamentous HemagglutininR01AI094991 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COTTER, PEGGY A · 2012 to 2016
$2.0M
Identifying the Bordetella PlrSR regulonR21AI177818 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOURRET, ROBERT B., COTTER, PEGGY A · 2023 to 2024
$432k
National Institute of Allergy and Infectious Diseases R01 AI153160-A1, R21 AI177818, R01 AI129541, R01 AI43986, R01 AI094991NIAID NIH HHS R01 AI043986NIAID NIH HHS R01 AI094991NIAID NIH HHS R01 AI129541NIAID NIH HHS R01 AI153160NIAID NIH HHS R21 AI177818
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adenylate Cyclase ToxinBordetella bronchisepticaBordetella pertussisAcylationAnimalsBordetella InfectionsHumansMacrophagesMiceVirulenceAdenylate Cyclase Toxinacylationadenylate cyclase toxinbacterial respiratory infectionBordetellaBordetella bronchisepticaBordetella pertussispost-translational modification

Identifiers

PMID40387377
PMCPMC12153271

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.