ArticleJournal of virology2025
The role of cysteine-rich protein in enhancing mandarivirus infectivity and pathogenicity.
Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Mandariviruses pose a significant threat to the citrus industry due to their diverse transmission modes and high pathogenicity. However, the pathogenicity mechanisms of mandariviruses remain largely unknown, especially as there is a complete lack of understanding regarding the function of the cysteine-rich proteins (CRPs) encoded by mandariviruses during infection. In this study, ectopic expression of two mandarivirus CRPs from citrus yellow mottle-associated virus (CiYMaV) and citrus yellow vein clearing virus (CYVCV) using a potato virus X vector resulted in severe symptoms and increased viral accumulation in IMPORTANCE: Mandariviruses, infecting a wide range of citrus varieties, cause serious epidemics in Pakistan, India, Turkey, China, Iran, Italy, and America. However, little information is available about pathogenicity mechanisms of mandariviruses. Here, we confirmed the importance of two mandarivirus CRPs of citrus yellow mottle-associated virus (CiYMaV) and citrus yellow vein clearing virus (CYVCV) in disease symptom development and viral accumulation in citrus plants. Our study first provides evidence that CiYMaV and CYVCV CRPs, nonstructural proteins, act as pathogenicity determinants with multiple functions. This offers a broad understanding of functional repertoire within the mandariviruses proteome. Further investigation of the underlying mechanisms of how CRP, as a virulence factor, modulates plant immunity may suggest a possible new strategy for combating mandarivirus infection in the field.
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