Evidence map›Paper›PMID 40387358›Full record

ArticleJournal of virology2025

Basic patches on the E2 glycoprotein of eastern equine encephalitis virus influence viral vascular clearance and dissemination in mice.

Stephanie E Ander, Erin R Fish, Mariana O L da Silva, Bennett J Davenport, M Guston Parks, Thomas E Morrison

Abstract read
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stephanie E AnderDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0002-5527-723X
Erin R Fish *Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Mariana O L da Silva *Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Bennett J DavenportDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
M Guston ParksDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Thomas E MorrisonDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0002-1811-2938

Funding

TRAINING PROGRAM IN IMMUNOLOGYT32AI007405 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Laurel L Lenz, Raul Martin Torres · 1991 to 2026
$10.5M
Clearance of Blood-Borne ArbovirusesR01AI148144 · NIAID · UNIVERSITY OF COLORADO DENVER · PI MORRISON, THOMAS E · 2020 to 2025
$2.3M
Molecular mechanisms governing chikungunya virus binding, tropism, and pathogenesisR01AI173044 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Laurie A. Silva · 2024 to 2026
$2.0M
Defining the Molecular Determinants of Encephalitic Alphavirus ViremiaF32AI161866 · NIAID · UNIVERSITY OF COLORADO DENVER · PI ANDER, STEPHANIE · 2022 to 2023
$139k
NIAID NIH HHS F32 AI161866NIAID NIH HHS R01 AI148144NIAID NIH HHS R01 AI173044NIAID NIH HHS T32 AI007405
6 · The paper itself

Abstract

Previously, we found that chimeric Sindbis-eastern equine encephalitis virus (SINV-EEEV) particles can be removed from the murine blood circulation in a phagocyte-dependent manner which can be disrupted by either transient depletion of vascular heparan sulfate (HS) glycosaminoglycans (GAGs), or mutation of the viral E2 glycoprotein (K71/74/77A) associated with decreased GAG binding

Indexed as

Encephalitis Virus, Eastern EquineEncephalomyelitis, EquineViral Envelope ProteinsAnimalsBinding SitesDisease Models, AnimalFemaleHeparan SulfateMiceViremiaglycoprotein E2, Sindbis virusHeparan SulfateViral Envelope ProteinsAlphavirusEEEVglycosaminoglycanheparan sulfateviremia

Identifiers

PMID40387358
PMCPMC12172491

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.