SynthesisJournal of magnetic resonance imaging : JMRI2025
Characteristics and Pathologic Results of Foci on Breast Magnetic Resonance Imaging: A Systematic Review and Meta-Analysis.
Synthesis in Journal of magnetic resonance imaging : JMRI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Characteristics and Pathologic Results of Foci on Breast Magnetic Resonance Imaging: A Systematic Review and Meta-Analysis.Journal of magnetic resonance imaging : JMRI · 2025Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough T2-weighted imaging (T2WI) hypointensity, delayed enhancement washout pattern, interval growth, and new appearance of a focus have been associated with malignancy, the results are not consistent. PURPOSE: To investigate the malignancy rate and identify the clinical and imaging characteristics associated with malignancy among foci in breast MRI. STUDY TYPE: Meta-analysis. SUBJECTS: 32 articles with 2645 foci. FIELD STRENGTH/SEQUENCE: 1.5 T and 3.0 T. T1WI, T2WI, and DCE-MRI. ASSESSMENT: PubMed, Embase, Scopus, and Cochrane databases were searched for articles published from January 2013 to December 2023, using the search terms: "focus," "foci," "small mass," "size," "breast magnetic resonance imaging," and "breast MRI." Extracted data included the reference standard, number of benign/malignant foci, size criterion, BI-RADS categories, amount of fibroglandular tissue, background parenchymal enhancement, T2WI signal intensity, delayed enhancement pattern. STATISTICAL TESTS: Pooled data were analyzed using Revman 5.4 software. Between-study heterogeneity was investigated with I
resultsThe pooled malignancy rate of 2645 foci was 16% (95% CI: 13%-19%). There was a significant association between malignant foci and older age (OR = 5.82, 95% CI: 2.08-9.56), T2WI hypointensity (OR = 2.28, 95% CI: 1.19-4.35) and delayed enhancement washout pattern (OR = 2.78, 95% CI: 1.87-4.12). Hyperintense foci were significantly more likely to be benign (OR = 0.41, 95% CI: 0.21-0.79). DATA
conclusionAn enhancing focus with T2WI hypointensity and a washout pattern, especially in older patients, is significantly more likely to be malignant. Therefore, careful attention should be paid to it and could justify consideration of biopsy. EVIDENCE LEVEL: 3. TECHNICAL EFFICACY: Stage 3.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.