ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Trajectory of cognitive decline before and after incident arrhythmias in older adults: A 16-year population-based longitudinal cohort study.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Heterogeneity in the association between cardiovascular disease and cognitive decline: a pooled analysis of five prospective cohort studies from 24 countries.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Physical frailty, depressive symptoms, and cognitive decline before and after Parkinson's disease diagnosis: a population-based prospective study of the SHARE and ELSA cohorts.NPJ Parkinson's disease · 2026Article
- Physical function frailty trajectory before and after cardiovascular event among older adults in three multinational cohorts.BMC public health · 2026Article
- Hypergraph clustering for analyzing chronic disease patterns in mild cognitive impairment reversion and progression.Scientific reports · 2025Article
- Trajectory of cognitive decline before and after incident arrhythmias in older adults: A 16-year population-based longitudinal cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
introductionThe temporal pattern of cognitive decline before and after incident arrhythmias remains largely unknown.
methodsThis population-based cohort study included 6,494 participants (mean age: 62.9 ± 9.4 years) from the English Longitudinal Study of Ageing. Participants underwent a cognitive assessments at baseline and at least one subsequent time point.
resultsDuring a median follow-up of 12 years, 628 individuals were diagnosed with incident arrhythmias. Overall, the annual rate of cognitive decline before arrhythmia diagnosis among individuals who experienced incident arrhythmias was similar to that of participants who were free of arrhythmias throughout follow-up. No short-term cognitive decline was observed in participants with arrhythmia diagnosis after the event. Individuals with incident arrhythmias demonstrated a faster decline in global cognition (-0.042 standard deviation/year; 95% confidence interval: -0.065 to -0.019) over the years after arrhythmia diagnosis than before the event. DISCUSSION: Incident arrhythmias are associated with accelerated cognitive decline after, but not before, the event. HIGHLIGHTS: The annual rate of cognitive decline before arrhythmia diagnosis among individuals who experienced incident arrhythmias was similar to that of participants who were free of arrhythmias throughout follow-up. Incident arrhythmias were not associated with an acute decrease in global cognition, memory, or executive function at the time of the event. The rate of decline in global cognition and memory significantly accelerated over the years after arrhythmia diagnosis. Preventing arrhythmias may be important in reducing long-term cognitive decline.
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