Evidence map›Paper›PMID 40387162›Full record

ReviewTransplant infectious disease : an official journal of the Transplantation Society

Vaccine Adjuvants in the Immunocompromised Host: Science, Safety, and Efficacy.

Haya Hayek, Lana Hasan, Justin Z Amarin, Yasmeen Z Qwaider, Olla Hamdan, Wanderson Rezende, Kevin C Dee, James D Chappell, Natasha B Halasa

Abstract readReview
In one paragraph

Review in Transplant infectious disease : an official journal of the Transplantation Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Haya HayekDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0003-0087-4392
Lana HasanDepartment of Infectious Disease, Cleveland Clinic Foundation, Cleveland, Ohio, USA.ORCID https://orcid.org/0009-0001-0885-4217
Justin Z AmarinDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Yasmeen Z QwaiderDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Olla HamdanDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Wanderson RezendeDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Kevin C DeeDepartment of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
James D ChappellDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Natasha B HalasaDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0002-6381-1826

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccine adjuvants are essential for enhancing immune responses to vaccines, particularly in immunocompromised populations who typically demonstrate suboptimal responses to standard vaccination. This narrative review evaluates the safety and efficacy of approved and candidate adjuvants in immunocompromised hosts, with emphasis on solid organ and hematopoietic cell transplant recipients. We examine conventional aluminum-based adjuvants alongside modern adjuvant systems such as AS01

Indexed as

Adjuvants, ImmunologicAdjuvants, VaccineImmunocompromised HostVaccinesHematopoietic Stem Cell TransplantationHumansOrgan TransplantationSaponinsVaccinationAdjuvants, ImmunologicAdjuvants, VaccineSaponinsVaccines

Identifiers

PMID40387162
PMCPMC12247452

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.