Evidence map›Paper›PMID 40387138›Full record

ArticleThe journal of physical chemistry. B2025

Computational and Experimental Study of the Conformational Variation of the Catalytic Residue His41 of the SARS-CoV-2 Main Protease.

Jiao Zhou, Xiang Liu, Yan Xu, Juan Wang, Tingli Qian, Xiaohong Sang, Md Nazmul Hasan, Arieh Warshel, Jing An, Arjun Saha and 1 more

Abstract read
In one paragraph

Article in The journal of physical chemistry. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jiao ZhouCiechanover Institute of Precision and Regenerative Medicine, School of Medicine, Chinese University of Hong Kong, Shenzhen 518172, China.ORCID 0000-0002-4015-427X
Xiang LiuSchool of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan 528458, China.ORCID 0000-0001-6973-3809
Yan XuDepartment of Medicine, Division of Infectious Diseases and Global Public Health, School of Medicine, University of California at San Diego, La Jolla, California 92037, United States.
Juan WangSchool of Life Sciences, Tsinghua University, Beijing 100084, China.
Tingli QianCiechanover Institute of Precision and Regenerative Medicine, School of Medicine, Chinese University of Hong Kong, Shenzhen 518172, China.ORCID 0009-0005-8913-5415
Xiaohong SangCiechanover Institute of Precision and Regenerative Medicine, School of Medicine, Chinese University of Hong Kong, Shenzhen 518172, China.ORCID 0009-0002-6561-2254
Md Nazmul HasanDepartment of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States.ORCID 0000-0001-7403-1772
Arieh WarshelDepartment of Chemistry, University of Southern California, Los Angeles, California 90089, United States.ORCID 0000-0001-7971-5401
Jing AnDepartment of Medicine, Division of Infectious Diseases and Global Public Health, School of Medicine, University of California at San Diego, La Jolla, California 92037, United States.
Arjun SahaDepartment of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, United States.ORCID 0000-0003-1198-1820
Ziwei HuangCiechanover Institute of Precision and Regenerative Medicine, School of Medicine, Chinese University of Hong Kong, Shenzhen 518172, China.

Funding

Multiscale Simulations of Biological Systems and ProcessesR35GM122472 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARIEH WARSHEL · 2017 to 2026
$5.0M
NIGMS NIH HHS R35 GM122472
6 · The paper itself

Abstract

The main protease (M

Indexed as

Antiviral AgentsCoronavirus 3C ProteasesHistidineProtease InhibitorsSARS-CoV-2Catalytic DomainHumansMolecular Dynamics SimulationProtein ConformationStructure-Activity Relationship3C-like proteinase, SARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesHistidineProtease Inhibitors

Identifiers

PMID40387138
PMCPMC12413198

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.