Evidence map›Paper›PMID 40386939›Full record

ArticleArthritis & rheumatology (Hoboken, N.J.)2025

Orchestration of Skin Pathology in Cutaneous Lupus Erythematosus by HLA Class I Down-Regulated Senescent Epidermal Basal Cells.

Sena Yamamoto, Yuki Saito, Tsukasa Sato, Seina Nakano, Dain Kasseki, Ayaka Nagao, Norihiro Miura, Kentaro Nagaoka, Arisa Kita, Maki Miyajima and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis & rheumatology (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sena YamamotoGraduate School of Health Sciences, Hokkaido University, Sapporo, Japan.
Yuki SaitoGraduate School of Health and Medical Sciences, Sapporo Medical University School of Health Sciences, and Department of Anatomy, Sapporo Medical University School of Medicine, Sapporo, Japan.ORCID https://orcid.org/0000-0002-7949-1628
Tsukasa SatoGraduate School of Health Sciences, Hokkaido University, Sapporo, Japan.
Seina NakanoDepartment of Health Sciences, School of Medicine, Hokkaido University, Sapporo, Japan.
Dain KassekiGraduate School of Health Sciences, Hokkaido University, Sapporo, Japan.
Ayaka NagaoGraduate School of Health Sciences, Hokkaido University, Sapporo, Japan.
Norihiro MiuraGraduate School of Health Sciences, Hokkaido University, Sapporo, Japan.
Kentaro NagaokaDepartment of Anatomy, Sapporo Medical University School of Medicine, Sapporo, Japan.
Arisa KitaDepartment of Anatomy, Sapporo Medical University School of Medicine, Sapporo, Japan.
Maki MiyajimaGraduate School of Health Sciences, Hokkaido University, Sapporo, Japan.
Shogo IjimaDepartment of Oral Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan.
Koji TaniguchiDepartment of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Atsushi NiidaHuman Genome Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Takako S ChikenjiGraduate School of Health Sciences, Hokkaido University, Sapporo, Japan.ORCID https://orcid.org/0000-0003-2832-3656

Funding

Akiyama Life Science FoundationJapan Agency for Medical Research and Development (AMED)Japan Science and Technology Agency JPMJFR225EJapan Science and Technology Agency JPMJSP2119Japan Society for the Promotion of Science JP21H03049Japan Society for the Promotion of Science JP21H03293Japan Society for the Promotion of Science JP22K19757Japan Society for the Promotion of Science JP23K18443
6 · The paper itself

Abstract

objectiveThis study investigates the role of senescent epidermal basal cells in cutaneous lupus erythematosus (CLE) pathogenesis using skin samples from patients with CLE and a mouse model of systemic lupus erythematosus (SLE).

methodsCellular senescence profiling used datasets from the NCBI GEO database and Accelerating Medicines Partnership (AMP) Phase 1-Metro. Gene array data from GSE184989 (CLE, n = 68; control, n = 4), single-cell RNA sequencing data from GSE186476 (CLE, n = 7; control, n = 14), and AMP Phase 1-Metro (SLE, n = 17) were used. In vitro experiments further examined the expression of p21

resultsp21

conclusionSenescent cells create a microenvironment that directs cytotoxic T cell-mediated responses against normal epidermis in patients with CLE, contributing to disease pathology. Targeting senescent cells and their signaling pathways may offer novel therapeutic strategies for patients with skin lesions from CLE and SLE.

Indexed as

Cellular SenescenceEpidermal CellsEpidermisHistocompatibility Antigens Class ILupus Erythematosus, CutaneousSkinAnimalsCyclin-Dependent Kinase Inhibitor p21Disease Models, AnimalDown-RegulationErbB ReceptorsFemaleHumansInterferon Type ILupus Erythematosus, SystemicMiceCDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p21ErbB ReceptorsHistocompatibility Antigens Class IInterferon Type I

Identifiers

PMID40386939
PMCPMC12750137

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.