Evidence map›Paper›PMID 40386891›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025

A Ketol-Acid Reductoisomerase Inhibitor That Has Antituberculosis and Herbicidal Activity.

Xin Lin, Julia L Kurz, Yong-Hong Li, Shun Jie Wun, Thierry Lonhienne, Ross P McGeary, Nicholas P West, Gerhard Schenk, Jian-Guo Wang, Luke W Guddat

Abstract read
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In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xin LinSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, 4072, Australia.
Julia L KurzSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, 4072, Australia.
Yong-Hong LiState-Key Laboratory and Research Institute of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, National Engineering Research Center of Pesticide, College of Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, China.
Shun Jie WunSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, 4072, Australia.
Thierry LonhienneSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, 4072, Australia.
Ross P McGearySchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, 4072, Australia.
Nicholas P WestSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, 4072, Australia.
Gerhard SchenkSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, 4072, Australia.
Jian-Guo WangState-Key Laboratory and Research Institute of Elemento-Organic Chemistry, Frontiers Science Center for New Organic Matter, National Engineering Research Center of Pesticide, College of Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, China.
Luke W GuddatSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, 4072, Australia.ORCID https://orcid.org/0000-0002-8204-8408

Funding

Australian Research Council DP210101802National Natural Science Foundation of China 22277060National Natural Science Foundation of China W2412124University of Queensland
6 · The paper itself

Abstract

Ketol-acid reductoisomerase (KARI) is a target for the development of new biocidal agents. This is based on its essential role in branched chain amino acid biosynthesis in plants and microorganisms, and its absence in animals. The lack of success in developing KARI inhibitors as biocides may be because the inhibitors assessed to date compete directly with the substrate, 2-acetolactate (AL). As a result, effectiveness diminishes when AL accumulates in cells. Furthermore, as these inhibitors are slow binding, an organism could avoid growth slowdown by increasing KARI production. Here, we show a pyrimidinedione, 1f is a competitive but time-dependent inhibitor of AL and NADPH for Mycobacterium tuberculosis (Mt) KARI (K

Indexed as

Antitubercular AgentsEnzyme InhibitorsHerbicidesKetol-Acid ReductoisomeraseMycobacterium tuberculosisBrassicaCrystallography, X-RayMicrobial Sensitivity TestsNADPOryzaStaphylococcus aureusAntitubercular AgentsEnzyme InhibitorsHerbicidesKetol-Acid ReductoisomeraseNADPcrystal structuredrug discoveryherbicide discoveryinhibitorKetol‐acid reductoisomerase

Identifiers

PMID40386891
PMCPMC12202844

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.