ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
UTX Responds to Nanotopography to Suppress Macrophage Inflammatory Response by Remodeling H3K27me3 Modification.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- UTX Responds to Nanotopography to Suppress Macrophage Inflammatory Response by Remodeling H3K27me3 Modification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- AI-driven biomaterial design: an intelligent closed loop from reverse design to biological response.Frontiers in cell and developmental biology · 2025Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Peri-implantitis is the leading cause of implant failure, primarily due to weak defense at the implant-soft tissue interface, which disrupts the local immune microenvironment. As an integral part of this microenvironment, the implant-tissue interface plays a critical role in shaping immune cell function. Thus, engineering the surface topography of implants has emerged as a novel strategy for sustained immunomodulation following implantation. This study investigated the mechanical regulation of macrophage function by nanopatterned topographies. Titanium nanotubes (TNTs) surfaces reduce the expression of phosphorylated myosin light chain (pMLC) and promote the retention of the UTX histone methyltransferase in the nucleus. This process attenuates the enrichment of the repressive H3K27me3 histone marker at the Abca1 gene locus, increasing Abca1 expression and suppressing inflammation. This study reveals the mechanosensitivity of UTX and provides a new target for the development of therapeutic strategies that integrate mechanical signaling and immune modulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.