Evidence map›Paper›PMID 40386682›Full record

ArticlePNAS nexus2025

Astrocyte

Micah Lefton, Carlos C Flores, Yuji Owada, Christopher J Davis, Thomas N Ferraro, Yool Lee, Wheaton L Schroeder, Jason R Gerstner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PNAS nexus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Micah LeftonElson S. Floyd College of Medicine, Washington State University, Spokane, WA 99202, USA.
Carlos C FloresElson S. Floyd College of Medicine, Washington State University, Spokane, WA 99202, USA.ORCID https://orcid.org/0000-0003-3771-0906
Yuji OwadaDepartment of Organ Anatomy, Graduate School of Medicine, Tohoku University, Seiryo-cho 2-1, Aobaku, Sendai 980-8575, Japan.
Christopher J DavisElson S. Floyd College of Medicine, Washington State University, Spokane, WA 99202, USA.ORCID https://orcid.org/0000-0002-9613-928X
Thomas N FerraroDepartment of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ 08103, USA.ORCID https://orcid.org/0000-0003-2250-8772
Yool LeeElson S. Floyd College of Medicine, Washington State University, Spokane, WA 99202, USA.ORCID https://orcid.org/0000-0003-0498-3342
Wheaton L SchroederVoiland College of Engineering and Architecture, Washington State University, 305 NE Spokane St, Pullman, WA 99164, USA.ORCID https://orcid.org/0000-0003-2302-1237
Jason R GerstnerElson S. Floyd College of Medicine, Washington State University, Spokane, WA 99202, USA.ORCID https://orcid.org/0000-0003-3113-6974

Funding

Characterizing evolutionarily conserved mechanisms underlying sleep, clocks, and memoryR35GM133440 · NIGMS · WASHINGTON STATE UNIVERSITY · PI GERSTNER, JASON ROBERT · 2019 to 2023
$2.3M
NIGMS NIH HHS R35 GM133440
6 · The paper itself

Abstract

Epileptic seizures often track with time of day and/or changes in vigilance state; however, specific molecular and cellular mechanisms driving the ictal and temporal associations are lacking. Astrocytes are a type of glial cell known to modulate neuronal excitability and circadian rhythms. These cells also abundantly express fatty acid-binding protein 7 (Fabp7), a clock-driven molecule necessary for normal sleep regulation, lipid signaling, and gene transcription. To determine whether Fabp7 influences time-of-day-dependent seizure susceptibility, we tested male C57/BL6N wild-type (WT) and

Indexed as

blbpcircadianexcitabilitygliatranscription

Identifiers

PMID40386682
PMCPMC12082287

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.