ArticleJournal of gastrointestinal oncology2025
Inhibition of hepatocellular carcinoma progression by artesunate via modulation of the TLR4/MyD88/NF-κB signaling pathway.
Article in Journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Mechanistic investigation of artesunate against head and neck squamous cell carcinoma through network pharmacology and experimental validation.Discover oncology · 2026Article
- Artesunate directly targeting MMP9 to reduce angiogenesis and increase CD8 + T cell infiltration inhibits hepatocellular carcinoma.Cancer cell international · 2026Article
- The Triad of NF-κB, HIF-1α, and Oxidative Stress in Hepatocellular Carcinoma: Pathogenesis, Clinical Challenges, and Therapeutic Potential of CIGB-552 in Liver Transplantation.International journal of biological sciences · 2026Review
- Protective effect of hesperetin against myelosuppression and splenic inflammation via modulating TLR4/MYD88/NF-κB signaling: molecular docking and experimental validation.Frontiers in pharmacology · 2026Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Liver cancer remains a frequent cause of cancer-related death, and thus targeted drugs urgently need to be developed. Artesunate (ART) inhibits the progression of liver cancer; however, its mechanism of action remains unclear. The primary aim of this study is to clarify whether ART inhibits the progression of hepatocellular carcinoma (HCC) cells by suppressing the Toll-like receptor 4 (TLR4)/MyD88/nuclear factor (NF)-κB pathway. Methods: Results: The study showed that ART inhibits HCC cell proliferation, invasion, and migration and induces apoptosis in a dose-dependent manner. Conclusions: These results indicate that ART has a potent effect on the development of HCC cells, the underlying mechanisms of which may be associated with alterations in the TLR4/MyD88/NF-κB signaling pathway in HCC. Therefore, further development of ART as a therapeutic agent is warranted.
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Registered trials
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