Evidence map›Paper›PMID 40386586›Full record

ArticleJournal of gastrointestinal oncology2025

Metastatic pancreatic acinar cell carcinoma with

Shuhei Sugata, Atsushi Yamaguchi, Hiroki Kamada, Shigeaki Semba, Naohiro Kato, Yuji Teraoka, Takeshi Mizumoto, Yuzuru Tamaru, Tsuyoshi Hatakeyama, Hirotaka Kouno and 7 more

Abstract readCase Reports
In one paragraph

Article in Journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Shuhei SugataDepartment of Gastroenterology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.
Atsushi YamaguchiDepartment of Gastroenterology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.ORCID https://orcid.org/0000-0001-6916-4108
Hiroki KamadaDepartment of Endoscopy, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.
Shigeaki SembaDepartment of Endoscopy, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.
Naohiro KatoDepartment of Endoscopy, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.
Yuji TeraokaDepartment of Gastroenterology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.
Takeshi MizumotoDepartment of Endoscopy, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.
Yuzuru TamaruDepartment of Endoscopy, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.
Tsuyoshi HatakeyamaDepartment of Endoscopy, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.
Hirotaka KounoDepartment of Gastroenterology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.
Yoshiyuki ShibataDepartment of Surgery, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.
Sho TazumaDepartment of Surgery, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.
Takeshi SudoDepartment of Surgery, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.
Rie YamamotoDepartment of Pathology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.
Kazuya KuraokaDepartment of Pathology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.
Shigeto YoshidaDepartment of Endoscopy, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Japan.
Shiro OkaDepartment of Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Pancreatic acinar cell carcinoma (PACC) is a rare subtype of pancreatic cancer, and its clinicopathological behavior is not fully understood because of its rarity. The excision of the tumor is the best treatment, but PACC patients often have distant metastasis at the time of first diagnosis and sometimes have relapse after surgery. Thus, appropriate anti-tumor agents need to be administered; however, there is still no standard chemotherapy regimen for PACC. We report a case of PACC in a patient with breast cancer susceptibility gene ( Case Description: A 67-year-old man was treated for breast cancer in 2016. In 2022, he experienced a continuous left back pain, and abdominal computed tomography (CT) revealed a 47-mm hypo-dense mass in the pancreatic tail and a 100-mm slightly enhanced mass in the liver at segment 8. He was diagnosed with PACC with liver metastasis by liver and pancreatic tumor biopsies. He was started on mFFX and, at the same time, we performed an analysis of the Conclusions: mFFX might be prioritized as the first-line chemotherapy for PACC patients, and an analysis of the

Indexed as

Acinar cell carcinomabreast cancer susceptibility gene 2 (BRCA2)case reportFORFIRINOX (FFX)pancreatic cancer

Identifiers

PMID40386586
PMCPMC12078823

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.