Evidence map›Paper›PMID 40386573›Full record

ArticleArXiv2025

Surrogate modeling of Cellular-Potts Agent-Based Models as a segmentation task using the U-Net neural network architecture.

Tien Comlekoglu, J Quetzalcóatl Toledo-Marín, Tina Comlekoglu, Douglas W Desimone, Shayn M Peirce, Geoffrey Fox, James A Glazier

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In one paragraph

Article in ArXiv, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Tien ComlekogluDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
J Quetzalcóatl Toledo-MarínTRIUMF, Vancouver, BC, Canada.
Tina ComlekogluBeirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA, USA.
Douglas W DesimoneDepartment of Cell Biology, University of Virginia, Charlottesville, VA, USA.
Shayn M PeirceDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, USA.
Geoffrey FoxDepartment of Computer Science, University of Virginia, Charlottesville, VA, USA.
James A GlazierDepartment of Intelligent Systems Engineering, Indiana University, Bloomington, IN, USA.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007267 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI GARCIA-BLANCO, MARIANO A. · 1985 to 2024
$13.4M
Cell-Cell and Cell-Matrix Interactions in MorphogenesisR35GM131865 · NIGMS · UNIVERSITY OF VIRGINIA · PI DESIMONE, DOUGLAS W. · 2019 to 2023
$2.2M
Dissemination of libRoadRunner and CompuCell3DU24EB028887 · NIBIB · UNIVERSITY OF WASHINGTON · PI GLAZIER, JAMES ALEXANDER, SAURO, HERBERT M. · 2019 to 2023
$1.5M
Interdisciplinary Training in Systems & Biomolecular Data ScienceT32GM145443 · NIGMS · UNIVERSITY OF VIRGINIA · PI Kevin A Janes, Jason Papin · 2022 to 2026
$1.5M
NIBIB NIH HHS U24 EB028887NIGMS NIH HHS R35 GM131865NIGMS NIH HHS T32 GM007267NIGMS NIH HHS T32 GM145443
6 · The paper itself

Abstract

The Cellular-Potts model is a powerful and ubiquitous framework for developing computational models for simulating complex multicellular biological systems. Cellular-Potts models (CPMs) are often computationally expensive due to the explicit modeling of interactions among large numbers of individual model agents and diffusive fields described by partial differential equations (PDEs). In this work, we develop a convolutional neural network (CNN) surrogate model using a U-Net architecture that accounts for periodic boundary conditions. We use this model to accelerate the evaluation of a mechanistic CPM previously used to investigate

Identifiers

PMID40386573
PMCPMC12083699

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.