ArticleFrontiers in oncology2025
PIGR predicts good clinical outcomes and plays a tumor suppressor role in the development of breast cancer.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- IgG Fc binding protein (FCGBP) inhibits the development of laryngeal squamous cell carcinoma and cisplatin resistance through the PIGR/JAK2/STAT3 pathway.Radiology and oncology · 2026Article
- High expression of GRB14 is associated with cancer progression and poor prognosis in gastric cancer.Discover oncology · 2025Article
- Mediation Mendelian randomization study of plasma proteomics reveals the causal relationship and potential mechanisms between iron and colorectal adenocarcinoma.Discover oncology · 2025Article
- Article
- Integrating single-cell and bulk expression data to identify and analyze cancer prognosis-related genes.Heliyon · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Breast cancer (BRCA) is a phenotypically and functionally heterogeneous disease. New biomarkers or therapeutic targets must be discovered to improve treatment effects. The polymeric immunoglobulin receptor (PIGR) plays an anti-cancer role in various human malignancies. This study aimed to explore the prognostic significance and possible function of PIGR in BRCA. Methods: Data from TCGA and GEO, and methods such as logistic regression analysis, Kaplan-Meier survival analysis, multivariate Cox analysis, GO, KEGG, and GSEA were employed to detect the effects of PIGR on BRCA bioinformatically. RT-qPCR, Western blot analysis, and immunohistochemistry were used to validate the expression of PIGR in BRCA. The effects of PIGR on BRCA were also detected Results: The expression level of PIGR was down-regulated in BRCA tissues. CCK-8 proliferation and colony formation assay demonstrated that overexpression of PIGR could inhibit breast cancer cell proliferation, clone formation, and migration. Conclusions: PIGR can suppress breast cancer cell growth
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.