Evidence map›Paper›PMID 40386529›Full record

ArticleJournal of medical biochemistry2025

Analysis of significance of CARD11 and MYO1G expressions in pulmonary tuberculosis and their predictive value for prognosis of recurrence.

Fengxia Liu, Shengxun Lin, Li Li, Bei Xu, Tingting Chang

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Article in Journal of medical biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Fengxia LiuShandong University, Shandong Public Health Clinical Center, Department of Tuberculosis 7 Ward, Jinan, China.
Shengxun LinNantong Hospital of Shanghai University, The Sixth People's Hospital of Nantong, Nantong, Medical Laboratory, Nantong, China.
Li LiFeicheng People's Hospital, Department of Respiratory and Critical Care Medicine, Lung function room, Feicheng, China.
Bei XuJinan Fourth People's Hospital, Department of Infectious Diseases, Jinan, China.
Tingting ChangShandong University, Shandong Public Health Clinical Center, Department of Tuberculosis 7 Ward, Jinan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary tuberculosis (PTB) is one of the most common infectious diseases worldwide, with extremely high morbidity and mortality. An in-depth understanding of the molecular pathogenesis of PTB is crucial for finding novel diagnostic and therapeutic approaches in the future. In this study, we identified 52 differentially expressed genes (DEGs) from the GSE34608 dataset in the Gene Expression Omnibus (GEO) database, and the protein-protein interaction (PPI) network showed that these DEGs included 42 nodes and 20 edges. We found that CARD11 and MYO1G were closely associated with T cell activation by functional enrichment analysis. Upon further clinical case analysis, we found that the expressions of CARD11 and MYO1G in the peripheral blood of patients with PTB were lower than those of healthy individuals. Meanwhile, through Receiver operating characteristic (ROC) curve analysis, we found that CARD11 and MYO1G showed excellent diagnostic effects on the occurrence and prognosis of PTB recurrence. Thus, CARD11 and MYO1G are promising indicators for assessing PTB in the future.

Indexed as

analysis of biological informationCARD11MYO1Gpulmonary tuberculosisT cell activation

Identifiers

PMID40386529
PMCPMC12085172

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.