Evidence map›Paper›PMID 40386438›Full record

ArticleResearch square2025

Cervicovaginal microbiome alters transcriptomic and epigenomic signatures across cervicovaginal epithelial barriers.

Lauren Anton, Ana G Cristancho, Briana Ferguson, Jacques Ravel, Michal A Elovitz

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Lauren AntonUniversity of Pennsylvania.
Ana G CristanchoChildren's Hospital of Philadelphia, University of Pennsylvania.
Briana FergusonUniversity of Pennsylvania.
Jacques RavelUniversity of Maryland School of Medicine.
Michal A ElovitzIcahn School of Medicine at Mount Sinai.

Funding

Deciphering the Role of Vaginal Microbes in Preterm birthR01HD102318 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI ELOVITZ, MICHAL AVIVA · 2020 to 2024
$3.4M
Unraveling mechanisms by which cervicovaginal microbiota can promote or prevent cervical remodeling and preterm birthR01HD098867 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI ELOVITZ, MICHAL AVIVA · 2020 to 2024
$2.9M
Interrogation and Modulation of the Epigenome after Prenatal Hypoxic Brain InjuryK08NS119797 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI Ana Cristancho · 2022 to 2026
$1.1M
NICHD NIH HHS R01 HD098867NICHD NIH HHS R01 HD102318NINDS NIH HHS K08 NS119797
6 · The paper itself

Abstract

Background: The cervicovaginal microbiome plays a critical role in women's health, with microbial communities dominated by Results: In this study, we used RNA sequencing to characterize the transcriptional response of cervicovaginal epithelial cells exposed to the culture supernatants of common vaginal bacteria. Our findings revealed that Conclusions: These results provide new insights into host-microbe interactions within the lower reproductive tract and suggests that modulating the vaginal microbiome could offer innovative therapeutic strategies to improve reproductive health.

Indexed as

anti-microbial peptidesATAC-seqcervixchromatinepithelial cellsGardnerella vaginalisLactobacillus crispatusRNA-seqwomen’s health

Identifiers

PMID40386438
PMCPMC12083688

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.