ArticleResearch square2025
Xenoline-polarized macrophages as a physiologically relevant in vitro model of tumor-associated macrophages in glioblastoma.
Hasan Alrefai, Benjamin Lin, Amr Elkohly, Manoj Kumar, Taylor L Schanel, Kevin J Lee, Patricia H Hicks, Joshua C Anderson, Gao Guo, Eun-Young Erin Ahn and 2 more
Abstract readPreprint
In one paragraphArticle in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
12 authors.
Hasan AlrefaiThe University of Alabama at Birmingham.
Benjamin LinThe University of Alabama at Birmingham.
Amr ElkohlyThe University of Alabama at Birmingham.
Manoj KumarThe University of Alabama at Birmingham.
Taylor L SchanelThe University of Alabama at Birmingham.
Kevin J LeeThe University of Alabama at Birmingham.
Patricia H HicksThe University of Alabama at Birmingham.
Joshua C AndersonThe University of Alabama at Birmingham.
Gao GuoThe University of Alabama at Birmingham.
Eun-Young Erin AhnThe University of Alabama at Birmingham.
C Ryan MillerThe University of Alabama at Birmingham.
Christopher D WilleyThe University of Alabama at Birmingham.
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008361 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YACOUBIAN, TALENE ALENE · 1992 to 2024
$16.8MGlioblastoma tumor microenvironmental influence on acquired and inherent cancer therapy resistance.U01CA223976 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHEN, JAKE YUE, CUI, XIANGQIN · 2018 to 2022
$4.8MCredentialing next-generation human glioma models for precision therapeuticsR01CA258248 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Frank Furnari, Christopher Ryan Miller · 2022 to 2026
$3.0MGenetic and molecular basis of hematopoietic abnormalities in ZTTK syndromeR01HL168659 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Erin Eun-Young Ahn · 2023 to 2026
$2.1MTherapeutic targeting mesenchymal transition in newly diagnosed and recurrent GBMR01NS134798 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Frank Furnari, Christopher Ryan Miller · 2024 to 2026
$1.9MSON-mediated RNA splicing in glioblastomaR01CA236911 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AHN, ERIN EUN-YOUNG · 2020 to 2024
$1.8MTraining Program in Brain Tumor BiologyT32NS121721 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Anita Borton Hjelmeland · 2024 to 2026
$503kNCI NIH HHS R01 CA236911NCI NIH HHS R01 CA258248NCI NIH HHS U01 CA223976NHLBI NIH HHS R01 HL168659NIGMS NIH HHS T32 GM008361NINDS NIH HHS R01 NS134798NINDS NIH HHS T32 NS121721
6 · The paper itselfAbstract
Tumor-associated macrophages (TAMs) are the most abundant non-cancerous cell type in glioblastoma (GBM) and heavily influence GBM biology, contributing to tumor progression, therapeutic resistance, immune evasion, and neovascularization. Current
Identifiers
PMID40386422
PMCPMC12083673
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