Evidence map›Paper›PMID 40386410›Full record

ArticleResearch square2025

Paired mutation calling and spatial transcriptomics identify cellular neighbourhoods dictating the neoplastic outcome of colitis.

E B Moutin, L Chang, G Giavara, S Mehmed, M Colombé, F C Lourenço, M N Skoufou-Papoutsaki, R Kemp, P Gascard, T Tlsty and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

E B MoutinCRUK Cambridge Institute, University of Cambridge.ORCID 0000-0002-9029-1520
L ChangSchool of Mathematics, University of Birmingham.
G GiavaraCRUK Cambridge Institute, University of Cambridge.
S MehmedCRUK Cambridge Institute, University of Cambridge.ORCID 0009-0006-2178-618X
M ColombéCRUK Cambridge Institute, University of Cambridge.
F C LourençoCRUK Cambridge Institute, University of Cambridge.ORCID 0000-0002-9655-2488
M N Skoufou-PapoutsakiCRUK Cambridge Institute, University of Cambridge.
R KempCRUK Cambridge Institute, University of Cambridge.
P GascardDepartment of Pathology, University of California San Francisco.ORCID 0000-0001-5912-5228
T TlstyDepartment of Pathology, University of California San Francisco.
D S TourignySchool of Mathematics, University of Birmingham.ORCID 0000-0002-3987-8078
D J WintonCRUK Cambridge Institute, University of Cambridge.ORCID 0000-0001-6067-7927

Funding

Plastic States Associated with Cellular Stress and Malignancy: Insights for Prevention and Treatment of Lethal Metaplastic CancersR35CA197694 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TLSTY, THEA D · 2016 to 2022
$6.1M
Defining a Stromal Signature that Facilitates Progression of Lethal CancersR50CA211543 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GASCARD, PHILIPPE · 2019 to 2023
$1.2M
NCI NIH HHS R35 CA197694NCI NIH HHS R50 CA211543Wellcome Trust
6 · The paper itself

Abstract

In the progression from Inflammatory Bowel Disease to associated cancer, the clonal mutational landscape shifts from selection of mutations in inflammatory genes to selection of cancer-driver mutations

Identifiers

PMID40386410
PMCPMC12083657

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.