Evidence map›Paper›PMID 40386396›Full record

ArticleResearch square2025

Closed State Structure of the Pore Revealed by Uncoupled Shaker K+ Channel.

Francisco Bezanilla, Yichen Liu, Carlos Bassetto, Gustavo Contreras, Eduardo Perozo

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Francisco BezanillaUniversity of Chicago.ORCID 0000-0002-6663-7931
Yichen LiuUniversity of Chicago.ORCID 0000-0003-0774-6932
Carlos BassettoUniversity of Texas at San Antonio.ORCID 0000-0002-7012-5699
Gustavo ContrerasUniversity of Chicago.
Eduardo PerozoUniversity of Chicago.ORCID 0000-0001-7132-2793

Funding

The Electrophysiological Studies of Voltage Gated ChannelsR01GM030376 · NIGMS · UNIVERSITY OF CHICAGO · PI BEZANILLA, FRANCISCO J · 1985 to 2025
$9.1M
Structural Basis of Coupling and Dynamics in K+ ChannelsR01GM150272 · NIGMS · UNIVERSITY OF CHICAGO · PI Eduardo A Perozo · 2023 to 2026
$2.2M
Beagle-3: A Shared GPU Cluster for Biomolecular SciencesS10OD028655 · OD · UNIVERSITY OF CHICAGO · PI ROUX, BENOIT · 2020 to 2020
$2.0M
NIGMS NIH HHS R01 GM030376NIGMS NIH HHS R01 GM150272NIH HHS S10 OD028655
6 · The paper itself

Abstract

Voltage gated potassium (Kv) channels play key roles in physiological processes, from cellular excitability to immune response and are among the most important pharmaceutical targets

Identifiers

PMID40386396
PMCPMC12083643

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.