Evidence map›Paper›PMID 40386385›Full record

ArticleResearch square2025

Bladder activity of different PSMA PET radioligands and impact of furosemide.

Ismaheel Lawal, Aliza Mushtaq, Samuel Gitau, Khalid Makhdomi, Manali Rupji, Jeffrey Switchenko, Krishna Chaudhary, Ashesh Jani, David Schuster, Charles Marcus

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Ismaheel LawalEmory University.ORCID 0000-0003-4273-040X
Aliza MushtaqEmory University.
Samuel GitauAga Khan University Hospital.
Khalid MakhdomiAga Khan University Hospital.
Manali RupjiEmory University.
Jeffrey SwitchenkoEmory University.
Krishna ChaudharyEmory University.
Ashesh JaniEmory University.
David SchusterEmory University.
Charles MarcusMemorial Sloan Kettering Cancer Center.

Funding

Advanced PET-CT Directed Post-Prostatectomy Radiotherapy to Enhance Prostate Cancer OutcomesR01CA226992 · NCI · EMORY UNIVERSITY · PI JANI, ASHESH, SCHUSTER, DAVID MICHAEL · 2019 to 2023
$3.1M
NCI NIH HHS R01 CA226992
6 · The paper itself

Abstract

Background: Prostate-specific membrane antigen (PSMA) radioligands used for PET imaging of prostate cancer (PCa) have variable urinary excretion. The prostate bed region is an important site of disease localization where intense bladder activity may obscure lesion detection. We performed a comparative analysis of the bladder activity of different PSMA radioligands and investigated the impact of furosemide administration on bladder activity reduction. Methods: This is a retrospective analysis of PSMA PET/CT images of patients with PCa who were imaged with Results: 210 PSMA PET/CT studies were reviewed, including 50, 20, 20, 28, 42, and 50 completed with Conclusion: There is variation in the bladder radioactivity between the different PSMA radioligands for PCa PET imaging, with

Indexed as

18F-DCFPyL18F-PSMA-100718F-rhPSMA-7.368Ga-PSMA-11Bladder activityFurosemide

Identifiers

PMID40386385
PMCPMC12083678

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.