Evidence map›Paper›PMID 40386291›Full record

ArticleJBMR plus2025

Dietary menaquinone-9 supplementation does not influence bone tissue quality or bone mineral density during skeletal development in mice.

Minying Liu, Chongshan Liu, Nicolas Cevallos, Benjamin N Orbach, Christopher J Hernandez, Xueyan Fu, Jennifer Lee, Sarah L Booth, M Kyla Shea

Abstract read
In one paragraph

Article in JBMR plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Minying LiuUSDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, United States.ORCID https://orcid.org/0009-0007-1372-9000
Chongshan LiuOrthopaedic Surgery, University of California, San Francisco, CA 94143, United States.
Nicolas CevallosOrthopaedic Surgery, University of California, San Francisco, CA 94143, United States.
Benjamin N OrbachUSDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, United States.
Christopher J HernandezOrthopaedic Surgery, University of California, San Francisco, CA 94143, United States.ORCID https://orcid.org/0000-0002-0712-6533
Xueyan FuUSDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, United States.
Jennifer LeeUSDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, United States.
Sarah L BoothUSDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, United States.
M Kyla SheaUSDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, United States.ORCID https://orcid.org/0000-0002-3202-5582

Funding

The Microbiome and Bone StrengthR01AG067997 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HERNANDEZ, CHRISTOPHER JOHN · 2021 to 2025
$3.2M
NIA NIH HHS R01 AG067997
6 · The paper itself

Abstract

Vitamin K has been implicated in skeletal health because vitamin K-dependent proteins are present in bone tissue. While there are multiple forms of vitamin K, most research has focused on phylloquinone, which is found mainly in plant-based foods, and its metabolite menaquinone-4 (MK4). However, there are additional forms of vitamin K that are bacterially produced that appear to influence bone health but have not yet been studied extensively. Herein, we evaluated the effects of menaquinone-9 (MK9), a bacterially produced form of vitamin K, on bone tissue quality and density in young mice. Four-week-old male (

Indexed as

bone mineral densitybone tissue qualitymenaquinoneskeletal healthvitamin K

Identifiers

PMID40386291
PMCPMC12083984

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.