ArticleTranslational cancer research2025
Characteristics and clinical outcomes of early-onset gastrointestinal stromal tumors: a population‑based study.
Article in Translational cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Plexiform fibromyxoma of the lesser curvature of the stomach in a 16-year-old adolescent: A case report and literature review.Experimental and therapeutic medicine · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The incidence of gastrointestinal stromal tumors (GISTs) has risen, but early-onset GISTs (age <50 years) remain underexplored. This study aims to compare the clinical characteristics and prognostic outcomes of early-onset GISTs with later-onset cases (age ≥50 years). Methods: We conducted a retrospective study using data on GISTs diagnosed from 2000 to 2021 in the Surveillance, Epidemiology, and End Results (SEER) database. Prognostic factors for overall survival (OS) and cancer-specific survival (CSS) were analyzed using Cox regression and competing risk analysis. Kaplan-Meier and cumulative risk curves assessed survival disparities, and forest plots were used for subgroup analyses. Bias was minimized through multiple imputation, propensity score matching (PSM), and stratified regression. Results: Among 12,608 GIST cases, 2,271 (18%) were early-onset, and 10,337 (82%) were later-onset. Median age and survival for early-onset cases were 43 years and 70 months, respectively, Conclusions: Early-onset GISTs have distinct clinicopathological features and better OS and CSS compared to later-onset patients.
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