ReviewPeerJ2025
Mechanical loading regulates osteogenic differentiation and bone formation by modulating non-coding RNAs.
Review in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Xylosyltransferase-I serum activity is a promising biomarker for postmenopausal osteoporosis.Scientific reports · 2026Article
- Macrophage-MSCs Interplay in Orthodontic Bone Remodelling: Mechanics-Immunity-Stem Cell Axis.International dental journal · 2026Review
- Assessment of Factors Regulating Androgen Receptor (AR) and Estrogen Receptor Alpha (ERα) Expression in Men with End-Stage Hip Osteoarthritis.International journal of molecular sciences · 2026Article
- Effects of collagen peptide supplementation on bone turnover, cytokine, and inflammatory markers in female distance runners: a randomized pilot study.Frontiers in nutrition · 2026Article
- Advanced materials and devices strategies of mechanical stimulation for tissue regeneration.Regenerative biomaterials · 2026Review
- The Positive Effects of Exercise on Adolescent Growth and Development.Advances in experimental medicine and biology · 2026Review
- Yes-associated protein 1 in cancer: bridging mechanical transduction and epigenetic regulation.Cancer biology & therapy · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone tissue is highly responsive to mechanical stimuli, with mechanical loading serving as a crucial regulator of bone formation and resorption. The cellular transduction of mechanical loading involves intricate mechanisms, prominently featuring non-coding RNAs (ncRNAs). Various ncRNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), collaboratively regulate pathways involved in bone formation under mechanical loading. This article elucidates the mechanisms by which mechanical loading influences bone formation through ncRNAs, summarizing key ncRNAs and their regulatory pathways. Aimed at researchers and clinicians in molecular biology, orthopedics, and regenerative medicine, this study provides a theoretical foundation for the future application of mechanical loading to regulate osteogenic differentiation and offers insights into treating diseases associated with abnormal bone formation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.