ArticleFrontiers in nutrition2025
Nutritional status and systemic inflammation in COPD: prognostic value of the advanced lung cancer inflammation index.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Anemia and hemoglobin thresholds of 12.5 and 13.0 g/dL are associated with distinct cardiovascular and all-cause mortality risks in COPD.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- A novel protective role for SULF1 in chronic obstructive pulmonary disease through systemic compensation and binding to KRT15.Respiratory research · 2026Article
- Association of total fish-shellfish consumption with biological aging: a cross-sectional analysis of NHANES 1999-2020 with mediation by inflammatory and antioxidant biomarkers.Irish journal of medical science · 2026Article
- Impact of Nutritional Status and Sarcopenia on Acute Exacerbation Risk in Stable Chronic Obstructive Pulmonary Disease: A Retrospective Cohort Study.International journal of chronic obstructive pulmonary disease · 2026Article
- Association of the advanced lung cancer inflammation index and controlling nutritional status score with atrial fibrillation in COPD patients: a multicenter cross-sectional study.Frontiers in nutrition · 2026Article
- Development and validation of a sepsis-specific systemic inflammation classification system for mortality prediction.Frontiers in medicine · 2026Article
- Development and validation of prognostic models for bone metastasis in Non-Small cell lung cancer based on Machine learning algorithms.Journal of bone oncology · 2025Article
- Prognostic value of the advanced lung cancer inflammation index for 28 day mortality in sepsis associated acute kidney injury.Scientific reports · 2025Article
- Nutritional and Inflammatory Predictors of All-Cause Mortality in COPD Patients with Hypercapnic Respiratory Failure: A Two-Center Prospective Cohort Study.International journal of chronic obstructive pulmonary disease · 2025Observational
- Neutrophil-to-albumin ratio mediates the association between Life's Crucial 9 and chronic obstructive pulmonary disease.Frontiers in medicine · 2025Article
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13 authors.
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Abstract
Background: Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of global mortality, with systemic inflammation and malnutrition playing pivotal roles in its progression and outcomes. The Advanced Lung Cancer Inflammation Index (ALI), which integrates nutritional status and systemic inflammation, may offer potential prognostic value in COPD management. Objectives: This study aimed to evaluate the relationship between ALI and mortality outcomes in COPD patients, with a specific focus on the interplay between nutrition, inflammation, and their non-linear associations with all-cause and cardiovascular mortality. Methods: Data were derived from the NHANES (1999-2018) cohort, comprising 47,880 participants, including 1,960 COPD patients. ALI was calculated using body mass index (BMI), serum albumin levels, and the neutrophil-to-lymphocyte ratio (NLR). Survival analyses, including Kaplan-Meier curves, Cox proportional hazards models, and restricted cubic splines, were used to assess the association between ALI and mortality outcomes, exploring non-linear trends and thresholds. Results: Higher ALI levels were significantly associated with reduced risks of all-cause and cardiovascular mortality in COPD patients. Protective effects plateaued at ALI thresholds (88.32 for all-cause mortality and 89.73 for cardiovascular mortality), with mortality risks reversing at excessively high levels for cardiovascular mortality. Conclusion: ALI, as a composite marker of nutritional status and systemic inflammation, is a valuable prognostic tool for COPD patients. Its non-linear relationship with mortality underscores the need to optimize nutritional and inflammatory management strategies. These findings emphasize the critical importance of addressing malnutrition and systemic inflammation to improve COPD outcomes. Future research should validate these findings and investigate tailored nutritional interventions and anti-inflammatory treatments.
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