ArticleJournal of inflammation research2025
Seasonal Proteomic Variations and Biomarkers in Seasonal Allergic Rhinitis: Insights from Olink Inflammation Profiling.
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Bioassays in Allergy: Technical Characteristics, Limitations, and Pathways to Clinical Implementation-An EAACI Position Paper.Clinical and translational allergy · 2026Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Seasonal allergic rhinitis (SAR) is a prevalent inflammatory condition, yet its molecular mechanisms and reliable biomarkers remain incompletely understood. This study aimed to identify key inflammation-related proteins and pathways associated with SAR by investigating seasonal proteomic profile variations and their correlations with SAR symptoms. Patients and Methods: Serum samples were collected from nineteen SAR patients during both allergy (in-season, IS) and non-allergy (out-of-season, OS) periods. Differentially expressed proteins (DEPs) were identified using the Olink Target 96 Inflammation panel, which were further analyzed through Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. Spearman correlation analysis was conducted to explore associations between DEPs and SAR symptoms, including sneezing, rhinorrhea, nasal blockage, itchy nose, and itchy eye. Results: A total of 36 inflammation-related DEPs were identified, all significantly upregulated in the allergy season. Notable proteins such as glial cell line-derived neurotrophic factor (GDNF), interleukin-18 receptor 1 (IL-18R1), and interleukin-15 receptor alpha (IL-15RA) showed strong correlations with SAR symptoms. Sneezing was associated with IL-2 receptor beta (IL-2RB) ( Conclusion: This study identified key inflammation-related proteins and pathways that vary seasonally in SAR, offering insights into potential biomarkers and therapeutic targets for SAR management. Further studies are recommended to validate these findings in larger and more diverse populations.
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