ReviewFrontiers in genetics2025
Integrative genetic and epigenetic control of skeletal muscle fiber traits in agricultural animals.
Review in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Multi-Omics Insights Into the Mechanisms of Early Muscle Fiber Difference and Transformation Between Lean-Type and Chinese Indigenous Pigs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Global landscape of alternative polyadenylation during the growth and development of skeletal muscle in pigs.BMC genomics · 2026Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skeletal muscle fiber traits are fundamental to meat production and the meat quality of agricultural animals. The rich genetic resources and diverse phenotypic expression of muscle traits in agricultural animal species provide invaluable materials for investigating the genetic and molecular regulatory mechanisms underlying myofiber development and characteristics, optimizing breeding strategies, and developing models for human muscle-related diseases. This review presents an integrative perspective on the genetic and epigenetic regulation of skeletal muscle fiber development, incorporating evolutionary, genomic, epigenomic, and multi-omics insights. We focus on genetic architecture and causative or candidate genes for muscle fiber traits, as revealed by genome-wide association studies (GWAS) and selective sweep signatures, underscoring their adaptive significance and potential for selective breeding. The role of epigenetic mechanisms, such as DNA methylation, histone modifications, and non-coding RNAs, in linking genetic variation and phenotypic expression is also discussed. By synthesizing multi-omic data, we provide a comprehensive understanding of the molecular networks driving muscle fiber growth and differentiation. This review aims to consolidate current knowledge and offer actionable insights to advance research, breeding strategies, and applications in agricultural and biomedical fields.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.